mupirocin, mupirocin calcium (cont.)

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DOSING: For the treatment of impetigo, a small amount of the ointment is applied to the affected area, usually three times daily (every 8 hours). The area may be covered with a sterile gauze dressing. If there is no improvement in 3-5 days, the physician should be contacted to re-examine the infected area. For other skin infections, the cream is applied to the affected area 3 times a day for 10 days, and the doctor should be contacted as well if there is no improvement after 3-5 days.

When mupirocin is used for treating intranasal Staphylococcus aureus that are resistant to other antibiotics, patients who are age 12 years and older require the application of about half of the ointment from a single-use tube of ointment into one nostril and the other half into the other nostril. This treatment is repeated twice daily for 5 days. Currently, there is not enough information to recommend use of mupirocin in children younger than 12 years of age.

DRUG INTERACTIONS: There are no known drug interactions with mupirocin; however, it should not be used at the same time with other drugs that are applied inside the nose.

PREGNANCY: There are no adequate studies of mupirocin in pregnant women; however, studies in animals suggest no important effects on the fetus. Mupirocin, therefore, can be used in pregnancy if the physician feels that it is necessary.

NURSING MOTHERS: There is no information on the safety of mupirocin in nursing infants. It is unknown if any of the small amount of mupirocin that is absorbed from the skin into the blood of the mother concentrates in breast milk. It is advisable, therefore, not to nurse while using mupirocin.

SIDE EFFECTS: Side effects are uncommon and mild with mupirocin. The most frequent side effects are burning, stinging, pain, and itching at the area of application.

The intranasal use of mupirocin can cause headache (1 of every 11 patients), runny nose (1 in 17 patients), congestion (1 in 20 patients), sore throat (1 in 22 patients), changes in taste perception (1 in 30 patients), nasal irritation (1 in 50 patients) and cough (1 in 50 patients).

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 10/8/2014


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