mupirocin, mupirocin calcium

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GENERIC NAME: mupirocin, mupirocin calcium

BRAND NAME: Bactroban, Bactroban Nasal, Centany

DRUG CLASS AND MECHANISM: Mupirocin is an antibiotic that is used topically (on the skin) for the treatment of impetigo, a bacterial disease of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus and Streptococcus pyogenes. It also is used intranasally (inside the nose) by patients and some people who work in healthcare centers to eliminate methicillin-resistant Staphylococcus aureus (MRSA) that have colonized the inside of the nose.

Unlike most other antibiotics which act on either bacterial DNA or the walls of bacteria, mupirocin blocks the activity of an enzyme called isoleucyl-tRNA synthetase within the bacteria. This enzyme is necessary in order for the bacteria to make proteins. Without the ability to make proteins, the bacteria die. Because of its unique mechanism of action, there is little chance that bacteria will have become resistant to mupirocin because of exposure to other antibiotics. Mupirocin topical cream was approved by the FDA in December, 1987. The intranasal form was approved in October 1995.

Medically Reviewed by a Doctor on 10/8/2014

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