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February 9, 2012

Mumps (cont.)

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What is the history of mumps?

Medical historians believe that documentation of a clinical illness consistent with mumps dates back to Greco-Roman times. The first effective vaccine against mumps was introduced in 1948 and used from 1950-1978. Unfortunately, this vaccine strain had limited long-term immune memory effectiveness. The current strain used in the United States and worldwide provides over 80% long-term immunity. The current childhood mumps immunization schedule recommends vaccination at 1 and 4 years of age. The mumps vaccine is commonly administered as part of a combination vaccine (MMR) also providing protection against measles and rubella (German measles).

What causes mumps? How is mumps transmitted?

Mumps virus is a single strand of RNA housed inside a two-layered envelope that provides the virus its characteristic immune signature. Only one type of mumps virus has been demonstrated to exist (in contrast to multiple virus types which may cause the common cold).

Mumps is highly contagious and has a rapid spread among members living in close quarters. The virus most commonly is spread directly from one person to another via respiratory droplets. Less frequently, the respiratory droplets may land on fomites (sheets, pillows, clothing) and then be transmitted via hand-to-mouth contact after touching such items. The incubation period from exposure to the virus and onset of symptoms is approximately 14-18 days. Viral shedding is short lived and a patient should be isolated from other susceptible individuals for the first five days following the onset of swelling of the salivary (parotid) glands.

What are the signs and symptoms of mumps in children and adults?

Nonspecific symptoms of low-grade fever, headache, muscle aches (myalgia), reduced appetite, and malaise occur during the first 48 hours of mumps infection. Parotid gland swelling characteristically is present on day three of illness. (The parotid gland is a salivary gland located anterior to the ear and above the angle of the jaw -- imagine a large set of sideburns.) The parotid gland is swollen and tender to touch, and referred pain to the ear may also occur. Parotid gland swelling may last up to 10 days, and adults generally experience worse symptoms than children. Approximately 95% of individuals who develop symptoms of mumps will experience tender inflammation of their parotid glands.

Interestingly about 15%-20% of mumps cases have no clinical evidence of infection, and 50% of patients will have only nonspecific respiratory symptoms and not the characteristic description above. Adults are more likely to experience such a subclinical or respiratory-only constellation of symptoms while children between 2-9 years of age are more likely to experience the classic presentation of mumps with parotid gland swelling.


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