Rare allergic reactions have been described, such as hives and anaphylaxis (shock). Moxifloxacin should be used with caution in patients with central nervous system diseases such as seizures, because rare seizures have been reported in patients receiving moxifloxacin. Moxifloxacin should be avoided in children and adolescents less than 18 years of age, as safe use in these patients has not been established.
Moxifloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. This risk is especially increased in patients over 60 or patients taking corticosteroids ( for example prednisone). Many antibiotics, including moxifloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon, (C. difficile or pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting moxifloxacin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
Fluoroquinolones have neuromuscular blocking activity and can worsen muscles weakness in individuals with myasthenia gravis. They also worsen low blood glucose levels when combined with sulfonylureas (for example, glyburide [Micronase, Diabeta, Glynase, Prestab]).
REFERENCE: FDA Prescribing Information
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