moxifloxacin, Avelox

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

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DOSING: Acute bacterial sinus infection: Take 1 tablet (400 mg) by mouth or 400 mg injection once daily for 5 to 10 days.

Chronic bacterial bronchitis: Take 400 mg by mouth or injection once daily for 5 days.

Community-acquired pneumonia: Take 400 mg by mouth or injection once daily for 7 to 14 days.

Complicated skin and skin structure infections: Take 400 mg by mouth or injection once daily for 7 to 21 days.

Uncomplicated skin and skin structure infections: Take 400 mg by mouth or injection once daily for 7 days.

Complicated intra-abdominal infections: Take 400 mg by mouth or injection once daily for 5 to 14 days.

Safe and effective use of moxifloxacin is not established in patients under the age of 18 years.

DRUG INTERACTIONS: Moxifloxacin administration should be separated from aluminum and magnesium containing antacids, sucralfate (Carafate), and multivitamins because they can lower absorption of moxifloxacin and reduce its effectiveness. They should be administered 4 hours before or 8 hours after moxifloxacin.

Moxifloxacin should be used with caution with warfarin (Coumadin) because moxifloxacin can increase the effect of warfarin and risks of bleeding and bruising.

Moxifloxacin should be used with caution with sotalol (Betapace) because it can contribute to abnormal heart rhythm.

PREGNANCY: There are no adequate studies done on moxifloxacin to determine safe and effective use in pregnant women. It should only be used if clearly needed.

NURSING MOTHERS: Moxifloxacin enters breast milk. Mothers should decide whether to stop breastfeeding or discontinue moxifloxacin.

SIDE EFFECTS: Side effects of moxifloxacin are nausea, dizziness, diarrhea, QT prolongation, and photosensitivity.

Medically Reviewed by a Doctor on 10/7/2014

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