moxifloxacin-oral (cont.)
PRECAUTIONS: Before taking moxifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, levofloxacin); or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain heart rhythm disorders (QTc prolongation), untreated low blood potassium levels. Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain heart conditions (e.g., acute myocardial ischemia, cardiac arrhythmias, bradycardia), seizures, brain disorders (e.g., cerebral atherosclerosis, tumors, increased intracranial pressure), severe liver disease, joint/tendon problems (e.g., tendonitis, bursitis). This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects (e.g., tendon problems), especially if they are also taking corticosteroids (e.g., prednisone, hydrocortisone). Caution is advised when using this drug in children because they may be more sensitive to its possible side effects (e.g., joint/tendon problems). Discuss the risks and benefits with the doctor. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Moxifloxacin may pass into breast milk. Breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: See also the How to Use section. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain macrolide antibiotics (e.g., erythromycin, clarithromycin), corticosteroids (e.g., prednisone, hydrocortisone), live vaccines, warfarin, "water pills" (diuretics such as furosemide, hydrochlorothiazide). Report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with moxifloxacin, such as phenothiazines (e.g., thioridazine), tricyclic antidepressants (e.g., amitriptyline), isoniazid (INH), and theophylline, among others. Consult your doctor or pharmacist for details. Other drugs besides moxifloxacin which may affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, dofetilide, pimozide, quinidine, sotalol, procainamide, and sparfloxacin among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Do not start or stop any medicine without doctor or pharmacist approval.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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