Patients may also develop anemia with intrathecal injection, and pain at the injection site. The elderly may be more sensitive to adverse effects. Morphine has the potential to be habit forming. Tolerance and physical and psychological dependence may occur with prolonged use. Seizures may result from high doses. Overdoses may cause respiratory depression, coma, and death.
GENERIC AVAILABLE: Yes
PREPARATIONS: Solution 0.5, 2, 4, 5, 8, 10, 15, 25, and 50 mg/mL in 1, 2, 10, 20, 30, 50, and 250 mL ampules or vials. There is a preservative-free formulation for intrathecal and epidural (spinal) administration.
STORAGE: Morphine injection solution should be protected from light and stored at room temperature, between 15 C to 30 C (59 F to 86 F).
DOSING: Dosing is specific to the route of administration. In adults (at least 18 years of age) the initial intravenous dose should be 2 to 10 mg per 70 kg of body weight over 24 hours. For epidural administration, 5 mg may be administered initially, with a maximum dose of 10 mg over 24 hours. Initial dosing for intrathecal administration should be 0.2 to 1 mg over 24 hours.
DRUG INTERACTIONS: Combining alcohol and other sedatives with morphine can lead to increased sedation and even cause confusion.
Morphine should also be avoided in patients treated with monoamine oxidase inhibitors (MAOI) due to enhance toxicity of morphine including confusion, high blood pressure, tremor, hyperactivity, coma, and death. Drugs in this class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), and linezolid (Zyvox). Morphine should not be administered within 14 days of stopping an MAOI.
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