morphine high potency injection (Astramorph, Duramorph, Infumorph)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: Morphine for injection
BRAND NAMES: Astramorph, Duramorph, Infumorph
DRUG CLASS AND MECHANISM: Morphine is a chemical found in the opium plant. It is a narcotic (opiod) pain-reliever similar to hydrocodone, oxycodone, methadone, fentanyl, and other opioids. Morphine, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain (increasing the amount of stimulation it takes to feel pain) and reduce the perception of pain (the perceived importance of the pain). The FDA approved injectable morphine in October 1986.
GENERIC AVAILABLE: Yes
PREPARATIONS: Solution 0.5, 2, 4, 5, 8, 10, 15, 25, and 50 mg/mL in 1, 2, 10, 20, 30, 50, and 250 mL ampules or vials. There is a preservative-free formulation for intrathecal and epidural (spinal) administration.
STORAGE: Morphine injection solution should be protected from light and stored at room temperature, between 15 C to 30 C (59 F to 86 F).
PRESCRIBED FOR: Morphine through intravenous, epidural, or intrathecal injections is used for the management of moderate-to-severe acute and chronic pain that is not responsive to non-narcotic pain relievers.
DOSING: Dosing is specific to the route of administration. In adults (at least 18 years of age) the initial intravenous dose should be 2 to 10 mg per 70 kg of body weight over 24 hours. For epidural administration, 5 mg may be administered initially, with a maximum dose of 10 mg over 24 hours. Initial dosing for intrathecal administration should be 0.2 to 1 mg over 24 hours.
Medically Reviewed by a Doctor on 4/16/2014
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