PRECAUTIONS: Tell your doctor if you have: kidney problems, liver disease, thyroid disease, high blood pressure, allergies (especially drug allergies). Use caution when driving or operating machinery if this medication makes you drowsy or dizzy. Avoid excessive amounts of alcohol while taking this medication. Depending on your medical history, your doctor may choose to restrict your dietary intake of tyramine during and for 2 weeks following discontinuing the use of moclobemide. Certain foods and beverages are high in tyramine. Consult your doctor or pharmacist for details if needed. Though uncommon, depression itself can lead to thoughts or attempts of suicide. Tell your doctor immediately if you have any suicidal thoughts, or other mental/mood changes. Keep all medical appointments so your doctor can monitor your progress closely. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Small amounts of this medication appear in breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: apraclonidine, brimonidine, bethanidine, bupropion, buspirone, carbamazepine, dextromethorphan, entacapone, herbal products (e.g., ma huang), indoramin, meperidine, papaverine, sibutramine, SSRI antidepressants (e.g., fluoxetine, citalopram), sympathomimetics (e.g., methylphenidate, ephedrine), tolcapone, tricyclic antidepressants (e.g., amitriptyline, doxepin), "triptans" (e.g., sumatriptan, zolmitriptan). If you are currently using any of these medications, tell your doctor or pharmacist before starting moclobemide. Before using this medication, tell your doctor of all the medicines you use (both prescription and nonprescription), especially of: levodopa, insulin and oral diabetes drugs, other MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, tranylcypromine), sedatives, sleeping pills, blood pressure drugs. Do not start or stop any medicine without doctor or pharmacist approval.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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