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February 10, 2012
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moclobemide-oral tablet

GENERIC NAME: MOCLOBEMIDE - ORAL TABLET (mow-KLO-bem-ide)

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert

USES: This medication is used in the treatment of depression. It belongs to a class of drugs known as MAO inhibitors.

HOW TO USE: Take this medication by mouth immediately after meals as prescribed. Your dose may be adjusted gradually during the first weeks of therapy to find the dose just right for you. Follow dosing instructions closely. Do not take this more often, increase your dose or stop taking this without first consulting your doctor.

SIDE EFFECTS: This medication may initially cause dizziness, nervousness, mild headache, trouble sleeping and nausea as your body adjusts to the medication. Other side effects reported include sweating, loss of appetite, dry mouth, anxiety or blurred vision. If any of these effects continue or become bothersome, inform your doctor. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. Notify your doctor if you develop: rapid/pounding/irregular heartbeat, stomach pain, chest pain, sudden and severe headache, stiff neck, confusion, disorientation, slurred speech, behavioral changes, fever, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor if you have: kidney problems, liver disease, thyroid disease, high blood pressure, allergies (especially drug allergies). Use caution when driving or operating machinery if this medication makes you drowsy or dizzy. Avoid excessive amounts of alcohol while taking this medication. Depending on your medical history, your doctor may choose to restrict your dietary intake of tyramine during and for 2 weeks following discontinuing the use of moclobemide. Certain foods and beverages are high in tyramine. Consult your doctor or pharmacist for details if needed. Though uncommon, depression itself can lead to thoughts or attempts of suicide. Tell your doctor immediately if you have any suicidal thoughts, or other mental/mood changes. Keep all medical appointments so your doctor can monitor your progress closely. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Small amounts of this medication appear in breast milk. Consult your doctor before breast-feeding.




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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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moclobemide-oral tablet

What is a depressive disorder?

Depressive disorders have been with mankind since the beginning of recorded history. In the Bible, King David, as well as Job, suffered from this affliction. Hippocrates referred to depression as melancholia, which literally means black bile. Black bile, along with blood, phlegm, and yellow bile were the four humors (fluids) that described the basic medical physiology theory of that time. Depression, also referred to as clinical depression, has been portrayed in literature and the arts for hundreds of years, but what do we mean today when we refer to a depressive disorder? In the 19th century, depression was seen as an inherited weakness of temperament. In the first half of the 20th century, Freud linked the development of depression to guilt and conflict. John Cheever, the author and a modern sufferer of depressive disorder, wrote of conflict and experiences with his parents as influencing his development of depression.

In the 19...

Read the Depression article »


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