mitoxantrone (Novantrone)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Take the Leukemia Quiz

GENERIC NAME: mitoxantrone

DISCONTINUED BRAND: Novantrone

DRUG CLASS AND MECHANISM: Mitoxantrone is a synthetic (man-made) anticancer drug. It kills cancer cells by disrupting the action of deoxyribonucleic acids (DNA) in human cells by causing abnormal cross-links and breaks in the DNA. It also interferes with ribonucleic acid (RNA) and inhibits the activity of topoisomerase II, an enzyme that is necessary for repairing damaged DNA. The FDA approved mitoxantrone in December 1987.

PRESCRIBED FOR: Mitoxantrone is used for treating secondary progressive multiple sclerosis, acute nonlymphocytic leukemia, and patients with pain related to advanced hormone-refractory prostate cancer.

SIDE EFFECTS: The most common side effects of mitoxantrone are:

Other important side effects include

GENERIC AVAILABLE: Yes.

PRESCRIPTION: Yes.

PREPARATIONS: Injection: 20/10, 25/12.5, and 30 mg/15 ml

Medically Reviewed by a Doctor on 7/9/2015
Leukemia Quiz: Test Your Medical IQ
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Cancer Report Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors