GENERIC NAME: mitoxantrone
DISCONTINUED BRAND: Novantrone
DRUG CLASS AND MECHANISM: Mitoxantrone is a synthetic (man-made) anticancer drug. It kills cancer cells by disrupting the action of deoxyribonucleic acids (DNA) in human cells by causing abnormal cross-links and breaks in the DNA. It also interferes with ribonucleic acid (RNA) and inhibits the activity of topoisomerase II, an enzyme that is necessary for repairing damaged DNA. The FDA approved mitoxantrone in December 1987.
PRESCRIBED FOR: Mitoxantrone is used for treating secondary progressive multiple sclerosis, acute nonlymphocytic leukemia, and patients with pain related to advanced hormone-refractory prostate cancer.
SIDE EFFECTS: The most common side effects of mitoxantrone are:
- upper respiratory tract infections,
- hair loss (alopecia),
- interruption of menstruation,
- inflammation of the mouth (stomatitis).
Other important side effects include
GENERIC AVAILABLE: Yes.
PREPARATIONS: Injection: 20/10, 25/12.5, and 30 mg/15 ml
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