misoprostol, Cytotec (cont.)

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STORAGE: Tablets should be kept in a dry area with temperatures at or below 25 C (77 F)

PRESCRIBED FOR: Misoprostol is prescribed for the prevention of NSAID-induced gastric ulcers in patients at high risk for ulceration when treated with NSAIDs. Off-label (non-FDA approved) uses include fetal abortion, cervical ripening procedure during delivery, duodenal and gastric ulcer, and postpartum hemorrhage.

DOSING: The recommended adult oral dose for reducing the risk of NSAID-induced gastric ulcers is 200 mcg four times daily (every 6 hours) with food. If this dose cannot be tolerated, a dose of 100 mcg every 6 hours can be used. The last dose should be taken at bedtime.

For termination of pregnancy the dose is 400 mcg once if abortion has not occurred within 3 days of receiving mifepristone (Mifeprex).

DRUG INTERACTIONS: Misoprostol has no clinically important drug interactions.

PREGNANCY: Misoprostol should never be used during pregnancy since it can cause abortion, premature birth, or birth defects. Uterine rupture has been reported when misoprostol was administered to pregnant women to induce labor or to induce abortion beyond the eighth week of pregnancy.

NURSING MOTHERS: It is not known if misoprostol is excreted in human milk; however it should not be administered to nursing mothers because it could cause significant diarrhea in nursing infants.

SIDE EFFECTS: Common side effects include diarrhea and abdominal pain. Diarrhea is more common with higher doses and usually resolves with continued administration. Rarely, profound and persistent diarrhea necessitates stopping the drug. Less common side effects include headache, menstrual cramps, nausea, and flatulence. Allergic reactions have also been reported.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 9/17/2014


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