misoprostol, Cytotec

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

woman with abdominal pain

DOSING: The recommended adult oral dose for reducing the risk of NSAID-induced gastric ulcers is 200 mcg four times daily (every 6 hours) with food. If this dose cannot be tolerated, a dose of 100 mcg every 6 hours can be used. The last dose should be taken at bedtime.

For termination of pregnancy the dose is 400 mcg once if abortion has not occurred within 3 days of receiving mifepristone (Mifeprex).

DRUG INTERACTIONS: Misoprostol has no clinically important drug interactions.

PREGNANCY: Misoprostol should never be used during pregnancy since it can cause abortion, premature birth, or birth defects. Uterine rupture has been reported when misoprostol was administered to pregnant women to induce labor or to induce abortion beyond the eighth week of pregnancy.

NURSING MOTHERS: It is not known if misoprostol is excreted in human milk; however it should not be administered to nursing mothers because it could cause significant diarrhea in nursing infants.

SIDE EFFECTS: Common side effects include diarrhea and abdominal pain. Diarrhea is more common with higher doses and usually resolves with continued administration. Rarely, profound and persistent diarrhea necessitates stopping the drug. Less common side effects include headache, menstrual cramps, nausea, and flatulence. Allergic reactions have also been reported.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 9/17/2014

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