Adults (immediate-release tablets and capsules): The recommended dose for minocycline is: 200 mg initially, followed by 100 mg every 12 hours. If more frequent doses are preferred, then two or four 50 mg capsules initially, followed by 500 mg 4 times a day.
Children 8 years of age and older (immediate-release tablets and capsules): The recommended dose of minocycline is: 4 mg/kg initially, followed by 2 mg/kg every 12 hours, not to exceed the usual adult dose.
Adults and children 12 years of age and older (extended-release tablets): The recommended dose for minocycline is: Approximately 1 mg/kg by mouth once daily for up to 12 weeks for the treatment of inflammatory lesions of non-nodular acne vulgaris.
Safe and effective use of minocycline is not established for children under the age of 8.
Antacids containing aluminum, calcium, magnesium and iron-containing medications can bind with minocycline, delay the absorption, and reduce the effectiveness of minocycline.
Minocycline should be used with caution with oral contraceptives because it may decrease the effectiveness of oral contraceptives.
PREGNANCY: Minocycline should be avoided in pregnant women because it crosses the placenta and may cause fetal harm.
NURSING MOTHERS: Minocycline is excreted in human milk, and there is potential for serious adverse effects involving the development of teeth and bones in nursing infants. A decision should be made to discontinue medication or stop nursing, taking into account the importance of the drug to the mother.
REFERENCE: FDA Prescribing Information
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