Combining milnacipran with epinephrine or norepinephrine may lead to high blood pressure and abnormal heart beats because milnacipran increases epinephrine and norepinephrine.
Combining milnacipran with aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), warfarin (Coumadin) or other drugs that are associated with bleeding may increase the risk of bleeding, because milnacipran is associated with bleeding.
PREGNANCY: There are no adequate studies in pregnant women. Milnacipran should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
SIDE EFFECTS: The most frequent side effects include nausea, headache, constipation, dizziness, insomnia, flushing, excessive sweating, vomiting, palpitations, increased heart rate, dry mouth, and high blood pressure. Other side effects include seizures, hypertensive crisis, abnormal bleeding, low blood sodium (hyponatremia), and withdrawal syndrome.
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