miglitol, Glyset (cont.)

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Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects of miglitol are:

Rare but possible side effects include:



PREPARATIONS: Tablets: 25, 50 and 100 mg.

STORAGE: Miglitol should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in an air-tight container.


  • The initial miglitol dose may start at 25 mg three times daily and then increase after four to eight weeks to 50-100 mg three times daily.
  • The maximum dose is 100 mg three times daily.
  • Some patients may benefit from starting at 25 mg once daily to reduce the occurrence of upset stomach.
  • Miglitol should be taken at the first bite of each meal.
  • Smaller doses may be adequate for patients with severe kidney dysfunction.
  • Miglitol therapy is not advised in the presence of certain medical conditions such as inflammatory bowel disease (Crohn's disease or ulcerative colitis) or intestinal obstruction and chronic intestinal diseases involving difficulty with digestion or absorption such as Crohn's disease.
  • Miglitol doses should be adjusted based upon blood glucose levels taken one hour after a meal and blood HbA1c levels taken about three months after starting or changing the dose. (HbA1c is a chemical in the blood that is a good indicator of blood glucose control over a prolonged period of time.)

DRUG INTERACTIONS: Miglitol may interfere with digoxin (Lanoxin) absorption thereby decreasing digoxin blood levels and its effect. Therefore, the digoxin dose may need to be increased if miglitol is begun.

Medically Reviewed by a Doctor on 1/26/2015

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