miglitol, Glyset

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

PRESCRIBED FOR: It is believed that strict control of blood sugar in people with diabetes decreases the risk of eye, kidney, and nerve damage. Alpha-glucosidase inhibitors are used to help control blood sugar levels that are not controlled by diet and exercise alone. Miglitol is used in conjunction with diet and exercise for treating type 2 diabetes. It may be used alone or in combination with a sulfonylurea such as glyburide (Diabeta).

SIDE EFFECTS: The most common side effects of miglitol are:

Rare but possible side effects include:

  • low serum iron, and
  • skin rash.



PREPARATIONS: Tablets: 25, 50 and 100 mg.

STORAGE: Miglitol should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in an air-tight container.


  • The initial miglitol dose may start at 25 mg three times daily and then increase after four to eight weeks to 50-100 mg three times daily.
  • The maximum dose is 100 mg three times daily.
  • Some patients may benefit from starting at 25 mg once daily to reduce the occurrence of upset stomach.
  • Miglitol should be taken at the first bite of each meal.
  • Smaller doses may be adequate for patients with severe kidney dysfunction.
  • Miglitol therapy is not advised in the presence of certain medical conditions such as inflammatory bowel disease (Crohn's disease or ulcerative colitis) or intestinal obstruction and chronic intestinal diseases involving difficulty with digestion or absorption such as Crohn's disease.
  • Miglitol doses should be adjusted based upon blood glucose levels taken one hour after a meal and blood HbA1c levels taken about three months after starting or changing the dose. (HbA1c is a chemical in the blood that is a good indicator of blood glucose control over a prolonged period of time.)

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