- What is mifepristone-oral, and how does it work (mechanism of action)?
- What brand names are available for mifepristone-oral?
- Is mifepristone-oral available as a generic drug?
- Do I need a prescription for mifepristone-oral?
- What are the side effects of mifepristone-oral?
- What is the dosage for mifepristone-oral?
- Which drugs or supplements interact with mifepristone-oral?
- Is mifepristone-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about mifepristone-oral?
What is the dosage for mifepristone-oral?
Treatment with mifepristone and misoprostol requires three separate office visits.
- Day 1: Three 200 mg tablets (600 mg) of mifepristone are taken as a single dose.
- Day 3: 400 mcg of misoprostol is given orally unless abortion has been confirmed.
- Day 14: No medication administered. Patient returns for a post-treatment examination to confirm that a complete termination of pregnancy has occurred.
The dose for treating Cushing syndrome is 300 mg daily initially. The dose may be increased to 1200 mg daily.
Which drugs or supplements interact with mifepristone-oral?
Ketoconazole, itraconazole (Sporanox), erythromycin, and grapefruit juice may increase blood levels of mifepristone by inhibiting the enzyme responsible for metabolizing (breaking down) mifepristone. Rifampin, dexamethasone, St. John's Wort, phenytoin, phenobarbital, and carbamazepine may decrease blood levels of mifepristone by increasing the activity of the enzyme responsible for metabolizing mifepristone and decrease the effectiveness of mifepristone. Mifepristone may inhibit liver enzymes which are responsible for the metabolism of various drugs, resulting in increased blood levels of these drugs.
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