mifepristone, Mifeprex (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: Treatment with mifepristone and misoprostol requires three separate office visits.
The dose for treating Cushing syndrome is 300 mg daily initially. The dose may be increased to 1200 mg daily.
DRUG INTERACTIONS: Ketoconazole, itraconazole (Sporanox), erythromycin, and grapefruit juice may increase blood levels of mifepristone by inhibiting the enzyme responsible for metabolizing (breaking down) mifepristone. Rifampin, dexamethasone, St. John's Wort, phenytoin, phenobarbital, and carbamazepine may decrease blood levels of mifepristone by increasing the activity of the enzyme responsible for metabolizing mifepristone and decrease the effectiveness of mifepristone. Mifepristone may inhibit liver enzymes which are responsible for the metabolism of various drugs, resulting in increased blood levels of these drugs.
PREGNANCY: Mifepristone is used for the termination of pregnancy through the 49th day of pregnancy. Otherwise, it should not be used during pregnancy because it will terminate the pregnancy.
NURSING MOTHERS: Mifepristone is secreted into breast milk. Due to the risk of adverse effects, breastfeeding mothers should decide whether to discontinue breast-feeding or mifepristone.
Medically Reviewed by a Doctor on 10/30/2014
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Back to Medications Index
- Allergic Skin Disorders
- Bacterial Skin Diseases
- Bites and Infestations
- Diseases of Pigment
- Fungal Skin Diseases
- Medical Anatomy and Illustrations
- Noncancerous, Precancerous & Cancerous Tumors
- Oral Health Conditions
- Papules, Scales, Plaques and Eruptions
- Scalp, Hair and Nails
- Sexually Transmitted Diseases (STDs)
- Vascular, Lymphatic and Systemic Conditions
- Viral Skin Diseases
- Additional Skin Conditions