mifepristone, Mifeprex

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GENERIC NAME: mifepristone

BRAND NAME: Mifeprex, Korlym

DRUG CLASS AND MECHANISM: Mifepristone is a synthetic steroid with antiprogesterone and antiglucocorticoid effects. It is used for terminating pregnancy and treating people with Cushing syndrome. Progesterone is a female hormone and the principal progestational hormone. Progesterone prepares the uterus (the womb) to receive and sustain the fertilized egg andis an important hormone for sustaining pregnancy. Mifepristone terminates early pregnancy by blocking the activity of progesterone at progesterone receptors. It also stimulates contraction of the uterus. Early pregnancy is considered to be = 49 days (7weeks) since the last menstrual period began. Mifepristone must be used in combination with misoprostol for the purpose of termination of pregnancy. The FDA approved this combination treatment in September 2000.

Cortisol is a metabolite (break down product) of the hormone cortisone. Cortisol is an essential factor in many processes including the proper metabolism of starches, and it is the major natural glucocorticoid in humans. People with Cushing syndrome produce too much cortisol, and, among many other effects, develop high glucose (sugar) levels in the blood. Mifepristone reduces blood glucose levels in people with Cushing syndrome by blocking the activity of cortisol.



PREPARATIONS: Tablets: 200 and 300 mg

STORAGE: Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F). Optimal storage temperature is 25 C (77 F).

PRESCRIBED FOR: Mifepristone is used in combination with misoprostol for the termination of intrauterine pregnancy through day 49 of the pregnancy. It also is used for treating Cushing syndrome.

Medically Reviewed by a Doctor on 10/30/2014

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