midodrine (Orvaten, ProAmatine)

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GENERIC NAME: midodrine hydrochloride

BRAND NAME: Orvaten, ProAmatine

DRUG CLASS AND MECHANISM: Midodrine (Orvaten or ProAmatine) is an oral agent that is used to treat symptomatic orthostatic hypotension (low blood pressure). After oral administration, midodrine is converted into its active metabolite, desglymidodrine. Desglymidodrine is an alpha-1 agonist and is responsible for the pharmacological benefits of treatment. Desglymidodrine exerts its actions through activation of the alpha-adrenergic receptors in the arteries and veins which causes constriction of blood vessels and subsequent increase in blood pressure. Administration of midodrine results in an increase in standing, sitting, and supine systolic (horizontal position) and diastolic blood pressure in patient with orthostatic hypotension. Standing systolic blood pressure is increased by approximately 15 to 30 mmHg 1 hour after administration of a 10 mg dose of midodrine. Midodrine was approved by the US Food and Drug Administration (FDA) on September 6 1996.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 2.5 mg, 5 mg, 10 mg

STORAGE: Tablets should be stored at room temperature between 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Midodrine is used for the treatment of symptomatic orthostatic hypotension. Midodrine should be reserved for patients who have failed standard clinical care, including life style modifications, fluid expansion, and non-pharmacological treatments.

Medically Reviewed by a Doctor on 11/11/2014



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