midazolam injection, Versed (discontinued brand) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DRUG INTERACTIONS: Midazolam and all benzodiazepines interact with other medications and drugs that slow the brain's processes such as alcohol, barbiturates, narcotics, and tranquilizers. Boceprevir (Victrelis), itraconazole (Sporanox), nelfinavir (Viracept), and telaprevir (Incivek) increase blood level of midazolam by reducing its breakdown in the liver and, therefore can increase the side effects of midazolam.
PREGNANCY AND BREASTFEEDING SAFETY: Midazolam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Midazolam is best avoided if at all possible in the first trimester and probably throughout pregnancy.
Midazolam is secreted in breast milk.
STORAGE: Midazolam should be stored at room temperature, between 59 F and 86 F (15 C and 30 C) away from light and moisture.
DOSING: Midazolam is given by intramuscular or intravenous injection. The dose for sedation during surgery is 0.5 to 1 mg given over 2 minutes and not to exit 2.5 mg per dose. Doses may be repeated after 2 to 3 minutes. Total doses greater than 5 mg usually are not needed. The dose for starting anesthesia is 200 to 350 mcg/kg injected intravenously over 20 to 30 seconds.
Medically Reviewed by a Doctor on 1/5/2016
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