mibefradil-oral, Posicor (cont.)

SIDE EFFECTS: Generally this drug is well tolerated. Dizziness, headache, leg swelling, abdominal pain, nausea, unusual fatigue or nasal congestion might occur. If these persist or worsen, notify your doctor promptly. Very unlikely but report promptly: fainting spells, very slow heartbeat, breathing difficulties, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Before using this drug, tell your doctor your medical history, including: allergies (especially drug allergies), heart conditions, very low blood pressure, liver problems. To lessen the possible problem of feeling dizzy upon standing, stand up slowly from a lying or sitting position. This medication should be used only when clearly needed during pregnancy. Avoid use around the time of labor and birth. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medications you use, especially of: terfenadine, astemizole, cisapride, cyclosporine, tricyclic antidepressants (e.g., amitriptyline), tacrolimus, "statin" drugs (e.g., lovastatin), bepridil, cyclophosphamide, etoposide, erythromycin, flutamide, halofantrine, ifosfamide, pimozide, tamoxifen, thioridazine, vinblastine, vincristine. Also report the use of other heart drugs that affect the conduction system, such as: digoxin, beta-blockers (e.g., propranolol), other calcium blockers (e.g., verapamil), adenosine. If certain immunosuppressants (e.g., tacrolimus, cyclosporine) and any "statin" drugs for cholesterol are being used in combination, the manufacturer recommends avoiding mibefradil. The effects of mibefradil on other drugs can last for 14 days after stopping mibefradil. Consult your doctor or pharmacist. Do not start or stop any medicine without doctor or pharmacist approval.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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