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February 10, 2012
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metyrapone - oral, Metopirone

GENERIC NAME: METYRAPONE - ORAL (me-TIR-a-pone)

BRAND NAME(S): Metopirone

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: Normally the pituitary gland in your brain sends signals to your adrenal glands to make a natural substance called cortisol. Cortisol is important for keeping your body functioning well and for good health. Metyrapone is used to test if your pituitary gland is sending the proper signals to your adrenal glands.

HOW TO USE: Take this medication by mouth with milk or a snack as directed by your doctor.If you are directed to use the single-dose test, take your dose of metyrapone at midnight. Early the next morning, your doctor will take a blood sample from you.If you are directed to use the multiple-dose test, take this medication exactly at the times recommended by your doctor. For one day, several days before taking this medication, you will need to collect all your urine for a 24-hour period for testing, and then again on the day after you take this medication.It is important to take this medication as directed to assure proper test results.

SIDE EFFECTS: Nausea, upset stomach, headache, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking metyrapone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: decreased adrenal gland function (primary adrenal insufficiency), thyroid problems.This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. A below-normal response to this medication may occur in pregnant women.It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.




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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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metyrapone - oral, Metopirone

What is Cushing's syndrome?

Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. Sometimes called "hypercortisolism," it is relatively rare and most commonly affects adults aged 20 to 50. An estimated 10 to 15 of every million people are affected each year.

What are the symptoms of Cushing's syndrome?

Symptoms vary, but most people have upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. Children tend to be obese with slowed growth rates.

Other symptoms appear in the skin, which becomes fragile and thin. It bruises easily and heals poorly. Purplish pink stretch marks may appear on the abdomen, thighs, buttocks, arms and breasts. The bones are weakened, and routine activities such as bending, lifting or rising from a chair may lead to backaches, rib and spinal column fractures.

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