metronidazole gel, Metrogel, Metrocream, Metrolotion, Metrogel Vaginal, Vandazole (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Common side effects are:

  • skin irritation,
  • allergic reaction,
  • candida vaginitis during or shortly after therapy,
  • vaginal vulvar itching,
  • gastrointestinal cramps or pain,
  • nausea, and
  • metallic taste.

Other important side effects include:

  • bloating,
  • dark urine,
  • depression, and
  • skin rash



PREPARATIONS: Topical gel (0.75%, 1%), cream or lotion (0.75%): Vaginal gel (0.75%)

STORAGE: Topical forms of metronidazole should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: To treat rosacea, a thin film of metronidazole gel should be rubbed on affected areas once or twice daily. The usual dose of vaginal metronidazole gel is one applicator full (containing 37.5mg of metronidazole) intravaginally twice daily for five days. It should be applied once in the morning and once in the evening.

DRUG INTERACTIONS: Alcoholic beverages should not be consumed while being treated with metronidazole vaginal gel since this may result in headache, nausea, weakness, confusion, and even psychosis. This is the same reaction (disulfiram reaction) that occurs in alcoholics who drink alcohol while taking disulfiram (Antabuse), a drug used to discourage alcoholics from drinking alcohol.

Oral metronidazole interacts with warfarin (Coumadin), increasing the latter's blood-thinning properties. Little metronidazole is absorbed topically or from the vagina, and it is not known if the low blood levels achieved with topical or vaginal metronidazole can result in this interaction.

PREGNANCY: Animal studies have not demonstrated a risk to the fetus, but there are no adequate studies in pregnant women.

NURSING MOTHERS: Orally administered metronidazole is secreted in breast milk in concentrations that are similar to concentrations in the mother's blood. Although metronidazole concentration in blood after vaginal or topical administration is small, potential effects on the infant still should be considered.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 1/12/2015

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