metronidazole, Flagyl

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Tablets: 250 and 500 mg.
  • Tablets, extended release: 750 mg.
  • Capsule: 375 mg. Cream: 0.75% and 1%.
  • Lotion: 0.75%.
  • Gel: 0.75% and 1%.
  • Injection: 5 mg/ml

STORAGE: Metronidazole should be stored at room temperature and protected from light.

DOSING:

  • Metronidazole may be taken orally with or without food.
  • In the hospital, metronidazole can be administered intravenously to treat serious infections.
  • The liver is primarily responsible for eliminating metronidazole from the body, and doses may need to be reduced in patients with liver disease and abnormal liver function.

Various metronidazole regimens are used. Some examples are listed below.

  • Amebic dysentery: 750 mg orally 3 times daily for 5-10 days
  • Amebic liver abscess: 500-750 mg orally three times daily for 5-10 days
  • Anaerobic infections: 7.5 mg/kg orally or by injection every 6 hours for 7 to 10 days not to exceed 4 grams daily.
  • Bacterial vaginosis: 750 mg (extended release tablets) once daily for 7 days or 500 mg twice daily for 7 days or 2 g single dose orone applicator-full of 0.75% vaginal gel, once or twice daily for 5 days.
  • Clostridium difficile infection: 250-500 mg orally 4 times daily or 500-750 orally 3 times daily
  • Giardia: 250 mg orally three times daily for 5 days Helicobacter pylori: 800-1500 mg orally daily for several days in combination with other drugs.
  • Pelvic inflammatory disease (PID): 500 mg orally twice daily for 14 days in combination with other drugs.
  • Trichomoniasis: 2 g single dose or 1 g twice Rosacea: apply topical gel 0.75-1% once daily
Medically Reviewed by a Doctor on 12/17/2014

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