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- What is metolazone, and how does it work (mechanism of action)?
- What brand names are available for metolazone?
- Is metolazone available as a generic drug?
- Do I need a prescription for metolazone?
- What are the side effects of metolazone?
- What is the dosage for metolazone?
- Which drugs or supplements interact with metolazone?
- Is metolazone safe to take if I'm pregnant or breastfeeding?
- What else should I know about metolazone?
What is the dosage for metolazone?
The recommended dose is 2.5 to 5 mg for hypertension and 2.5-20 mg for treating edema.
Which drugs or supplements interact with metolazone?
Metolazone can reduce blood potassium and magnesium levels. This is especially true in patients who also are taking "loop" diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex ). Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients taking digoxin (Lanoxin). Metolazone reduces excretion of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity in patients receiving lithium. Steroids (for example, hydrocortisone) and nonsteroidal anti-inflammatory agents (NSAIDs) such as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone (Relafen) can reduce the effectiveness of metolazone by interfering with the excretion of salt and water.
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