- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is metolazone, and how does it work (mechanism of action)?
- What brand names are available for metolazone?
- Is metolazone available as a generic drug?
- Do I need a prescription for metolazone?
- What are the side effects of metolazone?
- What is the dosage for metolazone?
- Which drugs or supplements interact with metolazone?
- Is metolazone safe to take if I'm pregnant or breastfeeding?
- What else should I know about metolazone?
What is metolazone, and how does it work (mechanism of action)?
Metolazone is a diuretic ("water pill") used in the treatment of high blood pressure and fluid accumulation. It works by blocking salt and fluid retention by the kidneys, thereby increasing urinary output of salt and water (diuresis). Although it is not a true thiazide, metolazone is chemically related to the thiazide class of diuretics (for example, chlorthalidone [Hygroton], hydrochlorothiazide), and works in a similar manner. Zaroxolyn is the original formulation of metolazone, and Diulo is similar. The absorption of these two drugs is relatively incomplete. Mykrox has more complete absorption. Therefore, less Mykrox needs to be given to have the same effects as a larger dose of Zaroxolyn or Diulo. Metolazone was approved by the FDA in 1973.
What brand names are available for metolazone?
Is metolazone available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for metolazone?
What are the side effects of metolazone?
Metolazone generally is well tolerated. Common side effects of metolazone are:
- Hypokalemia (low blood potassium),
- (low blood sodium), and
- hypomagnesemia (low blood magnesium).
- Hypercalcemia (high blood calcium)
Thiazide diuretics, which are chemically related to metolazone, are known to increase the amount of uric acid in the blood. Precipitation of gout (which is associated with high uric acid) is rare. Metolazone can increase blood sugar in people with diabetes.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.