metolazone, Zaroxolyn, Diulo (Discontinued); Mykrox (Discontinued)

Pharmacy Author:
Medical and Pharmacy Editor:

GENERIC NAME: metolazone

BRAND NAME: Zaroxolyn, Diulo (Discontinued), Mykrox (Discontinued)

DRUG CLASS AND MECHANISM: Metolazone is a diuretic ("water pill") used in the treatment of high blood pressure and fluid accumulation. It works by blocking salt and fluid retention by the kidneys, thereby increasing urinary output of salt and water (diuresis). Although it is not a true thiazide, metolazone is chemically related to the thiazide class of diuretics (for example, chlorthalidone [Hygroton], hydrochlorothiazide), and works in a similar manner. Zaroxolyn is the original formulation of metolazone, and Diulo is similar. The absorption of these two drugs is relatively incomplete. Mykrox has more complete absorption. Therefore, less Mykrox needs to be given to have the same effects as a larger dose of Zaroxolyn or Diulo. Metolazone was approved by the FDA in 1973.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 2.5, 5, and 10 mg.

STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Metolazone is used in the treatment of high blood pressure and edema (fluid retention).




Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index