metoclopramide, Reglan, Reglan ODT, Metozol ODT, Octamide, (Maxolon discontinued) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Tablets: 5 and 10 mg.
  • Syrup: 5 mg/5 ml.
  • Injection: 5 mg/ml

STORAGE: Tablets and syrup should be stored between 15-30 C (59-86 F). Injectable metoclopramide should be stored at room temperature 20-25 C (68-77 F).

PRESCRIBED FOR: Metoclopramide is used on a short term basis (4 to 12 weeks) for treating patients with heartburn and esophagitis due to GERD and for treating patients who have gastroparesis. Metoclopramide is used to promote emptying of the stomach prior to radiological examinations and to facilitate passage of tubes passed through the nose or mouth and into the small intestine. It is used for treating impaired function of muscles of the small intestine that may give rise to symptoms that mimic intestinal obstruction (nausea, vomiting, and abdominal distention). Metoclopramide also is used in the treatment of nausea due to surgery or cancer chemotherapy.

DOSING:

The usual dose of metoclopramide for treating GERD is 10-15 mg four times daily, 30 minutes before each meal.

Gastroparesis is treated with 10 mg administered orally four times daily, 30 minutes before each meal and at bedtime.

DRUG INTERACTIONS: Since metoclopramide accelerates emptying of the stomach, it can increase or decrease absorption and effects of other drugs that are absorbed in the small intestine. For example, the effects of alcohol, diazepam (Valium) and cyclosporine can be accelerated when used together with metoclopramide. Conversely, metoclopramide may decrease the concentrations in blood of digoxin (Lanoxin) and cimetidine (Tagamet). Metoclopramide should not be used in patients taking MAO inhibitors for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), because of the risk of serious adverse effects due to excess release of neurotransmitters. Concurrent administration of anticholinergic drugs can decrease the effectiveness of metoclopramide.

PREGNANCY: The safety of metoclopramide in pregnancy has not been established.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index