- What is metoclopramide, and how does it work (mechanism of action)?
- What brand names are available for metoclopramide?
- Is metoclopramide available as a generic drug?
- Do I need a prescription for metoclopramide?
- What are the side effects of metoclopramide?
- What is the dosage for metoclopramide?
- Which drugs or supplements interact with metoclopramide?
- Is metoclopramide safe to take if I'm pregnant or breastfeeding?
- What else should I know about metoclopramide?
What is the dosage for metoclopramide?
The usual dose of metoclopramide for treating GERD is 10-15 mg four times daily, 30 minutes before each meal.
Gastroparesis is treated with 10 mg administered orally four times daily, 30 minutes before each meal and at bedtime.
Which drugs or supplements interact with metoclopramide?
Since metoclopramide accelerates emptying of the stomach, it can increase or decrease absorption and effects of other drugs that are absorbed in the small intestine. For example, the effects of alcohol, diazepam (Valium) and cyclosporine can be accelerated when used together with metoclopramide. Conversely, metoclopramide may decrease the concentrations in blood of digoxin (Lanoxin) and cimetidine (Tagamet). Metoclopramide should not be used in patients taking MAO inhibitors for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), because of the risk of serious adverse effects due to excess release of neurotransmitters. Concurrent administration of anticholinergic drugs can decrease the effectiveness of metoclopramide.
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