metoclopramide, Reglan, Reglan ODT, Metozol ODT, Octamide, (Maxolon discontinued) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY: The safety of metoclopramide in pregnancy has not been established.

NURSING MOTHERS: Metoclopramide is excreted in human breast milk. Nursing mothers should avoid metoclopramide during pregnancy.

SIDE EFFECTS: Metoclopramide is generally well-tolerated when used in low doses for brief periods. Neurological side effects increase with higher doses and longer periods of treatment. Common side effects of metoclopramide include drowsiness, restlessness, fatigue, anxiety, insomnia, depression, and sedation. The most serious neurological side effects of metoclopramide are symptoms mimicking Parkinson's disease, involuntary muscle movements, facial grimacing, and dystonic reactions resembling tetanus. Fortunately, these more serious side effects are infrequent and usually - though not always - disappear when metoclopramide is discontinued. Patients with Parkinson's disease can experience worsening of symptoms with metoclopramide. Metoclopramide may impair the mental and/or physical abilities to drive or operate machinery.

Reference: FDA Prescribing Information

Last Editorial Review: 1/7/2010

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