metoclopramide, Reglan, Metozolv ODT, (Reglan ODT, Octamide, and Maxolon

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GENERIC NAME: metoclopramide

BRAND NAME: Reglan, Metozolv ODT, (Reglan ODT, Octamide, and Maxolon are discontinued)

DRUG CLASS AND MECHANISM: Metoclopramide is a "prokinetic" drug that stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine by interacting with receptors for acetylcholine and dopamine on gastrointestinal muscles and nerves.

The lower esophageal sphincter, located between the esophagus and the stomach, normally prevents reflux of acid and other contents in the stomach from backing up into the esophagus. In patients with gastroesophageal reflux disease (GERD), a weakened lower esophageal sphincter allows reflux of stomach acid into the esophagus, causing heartburn and damage to the esophagus (esophagitis). Metoclopramide decreases the reflux of stomach acid by strengthening the muscle of the lower esophageal sphincter. Metoclopramide also stimulates the muscles of the stomach and thereby hastens emptying of solid and liquid meals from the stomach and into the intestines.

Medically Reviewed by a Doctor on 1/2/2015

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