HOW TO USE: When starting this medication, take it at night with food or milk to prevent stomach upset. As your doctor increases your dose, this medication is usually taken 2 to 3 times a day with meals. Your dosage depends on your condition and response to treatment.Your doctor may direct you to take a low dose at first, gradually increasing the dose to lower the chance of side effects such as nausea. Your doctor will adjust your dose to find the best dose for you. Follow your doctor's directions carefully. The usual maximum dose for adults is 12 milligrams of methysergide each day.Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day. If you are using this medication for headaches that occur in groups for periods of time (cluster headaches), it is usually taken only during the cluster and stopped after the cluster is over. Follow your doctor's directions carefully.Very serious side effects may occur when methysergide is taken continuously for a long time. Do not take methysergide for more than 6 months in a row. (See also Warning section.) This medication is for prevention. Do not use this medication to treat a current headache.Do not stop taking this medication without consulting your doctor. Your headaches may become worse ("rebound headache") when the drug is suddenly stopped. Your doctor will direct you to stop taking the medication by gradually lowering your dose over 2 to 3 weeks. After properly stopping the medication, do not take it again for 3 to 4 weeks as directed by your doctor.Methysergide usually starts to work in 1 to 2 days. Tell your doctor if your condition persists or worsens after 3 weeks.
SIDE EFFECTS: Nausea, vomiting, diarrhea, dizziness, drowsiness, stomach upset, heartburn, trouble sleeping, and flushing may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but very serious side effects occur: dizziness (especially upon standing), tingling/pain/coldness in the fingers/toes, whitish fingers/toes/nails, loss of feeling in the fingers/toes, bluish hands/feet, muscle pain/weakness, unusual weight gain.Seek immediate medical attention if any of these rare but very serious side effects occur: vision changes, confusion, slurred speech.A very serious scarring/thickening of the lining in the lungs, around the heart, and in the abdomen/pelvis may occur. Stop taking methysergide and tell your doctor immediately if any of these effects occur: shortness of breath, tightness/pain in the chest, slow/fast/irregular heartbeat, lower back pain, leg cramps, pain/redness/swelling of the legs/feet, severe stomach/abdominal pain, change in the amount/color of urine, difficult/painful urination, unusual weakness/tiredness.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, tell your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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