methylsulfonylmethane (msm) - oral

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS: Methylsulfonylmethane is available as tablets and powder, and is a component of many herbal products.

DRUG INTERACTIONS: There are no drug interactions listed for methylsulfonylmethane.

PREGNANCY AND BREASTFEEDING SAFETY: Use of methylsulfonylmethane during pregnancy has not been adequately evaluated.

It is not known whether methylsulfonylmethane is excreted in breast milk.

STORAGE: Methylsulfonylmethane should be stored at room temperature, 20 C to 25 C (68 F to 77 F).

DOSING: Typical doses adult dosages range from 500 to 8,000 mg daily with or after meals.

DRUG CLASS AND MECHANISM: Methylsulfonylmethane (MSM) is also called dimethyl sulfone, DMSO2, methyl sulfone, and many other names. Methylsulfonylmethane is an organic sulfur found in fruits, vegetables, grains, and milk as well as the urine of animals. It is an oxidation product of dimethyl sulfoxide (DMSO) and a source of sulfur for producing the amino acids methionine and cysteine. Methylsulfonylmethane is a water soluble white, odorless, crystalline compound that contains 34% elemental sulfur.

Methylsulfonylmethane reduces pain, inflammation, and allergic reactions. It also has wound healing, dermatologic, and exercise performance increasing effects.

Reference: Natural Medicines Database, Medscape

Medically Reviewed by a Doctor on 1/20/2016

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