STORAGE: Methylprednisolone preparations should be kept at room temperature, from 20 C to 25 C (68 F to 77 F).
DOSING: Dosage requirements of corticosteroids vary among individuals and the diseases being treated. In general, the lowest effective dose is used. The oral dose range is 2-60 mg daily depending on the disease. Depo-medrol doses are 10-80 mg injected into muscle every 1-2 weeks, and Solu-medrol doses are 10-250 mg intravenous or intramuscular injections up to 6 times daily. The initial dose should be adjusted based on response. Corticosteroids given in multiple doses throughout the day are more effective but also more toxic than the same total daily dose given once daily, or every other day.
Oral methylprednisolone should be taken with food.
PREGNANCY AND BREASTFEEDING SAFETY: Methylprednisolone has not been adequately evaluated in pregnant women.
Methylprednisolone has not been adequately evaluated in nursing mothers.
DRUG CLASS AND MECHANISM: Methylprednisolone family of products include methylprednisolone, methylprednisolone acetate (Medrol, Depo-medrol), and methylprednisolone sodium acetate (Solu-medrol). They will be called methylprednisolone in this monograph. They are synthetic (man-made) corticosteroids. Corticosteroids are naturally-occurring chemicals produced by the adrenal glands located adjacent to the kidneys. Corticosteroids affect metabolism in various ways and modify the immune system. Corticosteroids also block inflammation and are used in a wide variety of inflammatory diseases affecting many organs. The FDA approved methylprednisolone in October 1957.
Medically reviewed by Eni Williams, PharmD, PhD
Reference: FDA Prescribing Information
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