- Rheumatoid Arthritis Slideshow Pictures
- Take the RA Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is methylprednisolone, and how does it work (mechanism of action)?
- What brand names are available for methylprednisolone?
- Is methylprednisolone available as a generic drug?
- Do I need a prescription for methylprednisolone?
- What are the uses for methylprednisolone?
- What are the side effects of methylprednisolone?
- What is the dosage for methylprednisolone?
- Is methylprednisolone safe to take if I'm pregnant or breastfeeding?
- What else should I know about methylprednisolone?
What is methylprednisolone, and how does it work (mechanism of action)?
Methylprednisolone family of products include methylprednisolone, methylprednisolone acetate (Medrol, Depo-medrol), and methylprednisolone sodium acetate (Solu-medrol). They will be called methylprednisolone in this monograph. They are synthetic (man-made) corticosteroids. Corticosteroids are naturally-occurring chemicals produced by the adrenal glands located adjacent to the kidneys. Corticosteroids affect metabolism in various ways and modify the immune system. Corticosteroids also block inflammation and are used in a wide variety of inflammatory diseases affecting many organs. The FDA approved methylprednisolone in October 1957.
What brand names are available for methylprednisolone?
Medrol, Depo-Medrol, Solu-Medrol, A-Methapred
Is methylprednisolone available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for methylprednisolone?
What are the uses for methylprednisolone?
Methylprednisolone is used to achieve prompt suppression of inflammation. Examples of inflammatory conditions for which methylprednisolone is used include:
- rheumatoid arthritis,
- systemic lupus erythematosus,
- acute gouty arthritis,
- psoriatic arthritis,
- ulcerative colitis, and
- Crohn's disease.
Severe allergic conditions that fail conventional treatment also may respond to methylprednisolone. Examples include:
Chronic skin conditions treated with methylprednisolone include:
What are the side effects of methylprednisolone?
Adverse effects of methylprednisolone depend on dose, duration and frequency of administration. Short courses of methylprednisolone are usually well-tolerated with few, mild side effects. Long term, high doses of methylprednisolone may produce predictable and potentially serious side effects. Whenever possible, the lowest effective doses of methylprednisolone should be used for the shortest length of time to minimize side effects. Alternate day dosing also can help reduce side effects.
Side effects of methylprednisolone and other corticosteroids range from mild annoyances to serious irreversible bodily damage. Commonly reported side effects include:
- fluid retention,
- weight gain,
- high blood pressure,
- potassium loss,
- muscle weakness,
- puffiness of the face,
- hair growth on the face,
- thinning and easy bruising of the skin,
- peptic ulceration,
- worsening of diabetes,
- irregular menses,
- growth retardation in children,
- convulsions, and
- psychic disturbances.
Important psychic disturbances may include:
Quick GuideRheumatoid Arthritis (RA) Symptoms & Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.