GENERIC NAME: methylphenidate hydrochloride
BRAND NAME: Quillivant XR
DRUG CLASS AND MECHANISM: Methylphenidate is a medication used for treating attention deficit hyperactivity disorder (ADHD). It stimulates the central nervous system (CNS or brain) in a manner that is similar to amphetamines; however, its actions are milder than amphetamines. Amphetamines stimulate the brain by increasing the level of neurotransmitters, dopamine and norepinephrine, in the brain (neurotransmitters are chemicals produced by nerves that are released and attach to other nearby nerves as a means of communication among nerves). The exact mechanism of action of the drug in people with ADHD is unknown. Methylphenidate is the active ingredient in Ritalin and Concerta and is also available as pills and in a patch. FDA approved Methylphenidate suspension in September 2012.
GENERIC AVAILABLE: No
PREPARATIONS: Oral powder for suspension: 60 ml, 120 ml, 150 ml, and 180 ml containers.
STORAGE: Store methylphenidate suspension between 15 C to 30 C (59 F to 86 F).
DOSING: For patients 6 years of age and above, the recommended starting dose of methylphenidate suspension is 20 mg once daily in the morning, with or without food. The dose may be titrated weekly in increments of 10 mg to 20 mg. Daily doses above 60 mg have not been studied and are not recommended.
DRUG INTERACTIONS: Methylphenidate should not be combined with monoamine oxidase inhibitors (MAOIs) such as phenelzine (Nardil), selegiline (Zelapar, Emsam, and Eldepryl), tranylcypromine (Parnate), procarbazine (Matulane), rasagiline (Azilect), and isocarboxazid (Marplan) because of risks of hypertensive crisis. Use of methylphenidate and MAO inhibitors should be separated by at least 14 days.
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