Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Methyldopa may cause
anemia (low number of red blood cells). Before starting
treatment, doctors may order certain blood tests to check blood levels of red
blood cells. Additionally, periodic blood tests should be done during treatment
to detect hemolytic anemia (spontaneous break-down of red blood cells).
Methyldopa should be discontinued if hemolytic anemia occurs during treatment.
Methyldopa should be used cautiously in patients who have a history of liver
disease and should be avoided in patients with active
liver disease including
hepatitis and active
Methyldopa may cause water retention (edema or swelling of the legs) or
weight gain in some patients and, therefore, should be used cautiously in heart
Methyldopa is removed by certain types of
dialysis procedures. In certain
dialysis patients, hypertension (high blood pressure) has occurred as a result
of methyldopa being removed from the body during dialysis.
Methyldopa should be used cautiously in patients with cerebrovascular disease
because involuntary movements have been observed during treatment.
GENERIC AVAILABLE: Yes
PREPARATIONS: Oral tablets: 250 and 500 mg
STORAGE: Methyldopa should be stored at room temperature, between 15 C and 30 C 59 F and 86 F).
The usual starting dose of methyldopa for adults is 250 mg two or three times
a day in the first 48 hours.
If needed, the dosage may be increased or
decreased, preferably in intervals of no less than 48 hours (2 days).
methyldopa may cause sedation, evening administration is preferred.
methyldopa must be given with anti-hypertensive medications other than
the starting dose of methyldopa should be limited to 500 mg per day in divided
The usual maintenance dose of methyldopa for blood pressure control is 500 to
2 grams in two to four divided doses. The maximum recommended daily dosage is 3