Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
STORAGE: Methoxsalen lotion should be stored at 15 to 30 C (59 to 86 F)
Methoxsalen lotion should be applied to the affected area 2 hr. before UV
exposure every 3 to 7 days.
It takes a few weeks for pigmentation to begin.
Significant repigmentation may take 6 to 9 months of treatment and re-treatment
may be necessary to retain the new pigment.
DRUG CLASS AND MECHANISM:
Methoxsalen is a naturally occurring photoactive chemical found in the seeds
of the Ammi majus (Umbelliferae) plant and in the roots of Heraclem candicans.
It belongs to a group of compounds known as psoralens, or furocoumarins.
Methoxsalen lotion is used for treating vitiligo (leucoderma). The exact
mechanism of action of methoxsalen is not known.
Methoxsalen has several biological actions that may be responsible for its
medical effects. Methoxsalen is a photosensitizer that increases the reaction of
skin cells to UVA. Some experts suggest that methoxsalen improves vitiligo by
stimulating melanocytes (melanin forming skin cells) to move up the hair
follicle and to repopulate the epidermis. Methoxsalen also combines with DNA in
skin cells, leading to inhibition of DNA synthesis, cell division, and reduced
formation of new skin cells. Administration of methoxsalen combined with UVA
exposure causes cellular damage, leading to skin inflammation and erythema. The
damaged skin heals after several days to weeks.
The FDA approved methoxsalen lotion in December 1954.