- Psoriasis Slideshow: Symptoms, Causes and Treatment
- Psoriasis Quiz: Test Your Medical IQ
- Moderate to Severe Forms of Psoriasis Slideshow
- What is methoxsalen-topical, and how does it work (mechanism of action)?
- What brand names are available for methoxsalen-topical?
- Is methoxsalen-topical available as a generic drug?
- Do I need a prescription for methoxsalen-topical?
- What are the uses for methoxsalen-topical?
- What are the side effects of methoxsalen-topical?
- What is the dosage for methoxsalen-topical?
- Which drugs or supplements interact with methoxsalen-topical?
- Is methoxsalen-topical safe to take if I'm pregnant or breastfeeding?
- What else should I know about methoxsalen-topical?
What is methoxsalen-topical, and how does it work (mechanism of action)?
- Methoxsalen is a naturally occurring photoactive chemical found in the seeds of the Ammi majus (Umbelliferae) plant and in the roots of Heraclem candicans. It belongs to a group of compounds known as psoralens, or furocoumarins. Methoxsalen lotion is used for treating vitiligo (leucoderma). The exact mechanism of action of methoxsalen is not known.
- Methoxsalen has several biological actions that may be responsible for its medical effects. Methoxsalen is a photosensitizer that increases the reaction of skin cells to UVA. Some experts suggest that methoxsalen improves vitiligo by stimulating melanocytes (melanin forming skin cells) to move up the hair follicle and to repopulate the epidermis. Methoxsalen also combines with DNA in skin cells, leading to inhibition of DNA synthesis, cell division, and reduced formation of new skin cells. Administration of methoxsalen combined with UVA exposure causes cellular damage, leading to skin inflammation and erythema. The damaged skin heals after several days to weeks.
- The FDA approved methoxsalen lotion in December 1954.
What brand names are available for methoxsalen-topical?
Is methoxsalen-topical available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for methoxsalen-topical?
What are the uses for methoxsalen-topical?
- Methoxsalen lotion is a topical repigmenting agent for treating vitiligo (leucoderma). It is used in conjunction with controlled doses of ultraviolet A light (UVA, 320-400 nm) or sunlight.
What are the side effects of methoxsalen-topical?
Common side effects include:
Quick GuidePsoriasis Types, Images, Treatments
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.