methotrexate Related Diseases & Conditions

Medications are used to manage a variety of conditions. Our doctors have compiled a list of ailments that the medication methotrexate may be used to treat or manage.

  • Psoriasis Psoriasis is a long-term skin condition that may cause large plaques of red, raised skin, flakes of dry skin, and skin scales....learn more »
  • Liver Disease Liver disease can be cause by a variety of things including infection (hepatitis), diseases such as gallstones, high cholesterol...learn more »
  • Rheumatoid Arthritis Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as...learn more »
    In This Article
    Rheumatoid Arthritis Article
    • Rheumatoid arthritis (RA) facts
    • What is rheumatoid arthritis (RA)?
    • What are causes and risk factors of rheumatoid arthritis?
    • What are rheumatoid arthritis symptoms and signs?
    • What are complications of rheumatoid disease?
    • How do physicians diagnose rheumatoid arthritis?
    • What is the treatment for rheumatoid arthritis?
    • "First-line" rheumatoid arthritis medications
    • "Second-line" or "slow-acting" rheumatoid arthritis drugs
    • What are newer treatments for rheumatoid arthritis?
    • Rheumatoid arthritis diet and other treatments
    • What about rheumatoid arthritis and pregnancy?
    • What is the prognosis (outlook) for patients with rheumatoid arthritis?
    • Is it possible to prevent rheumatoid arthritis?
    • What research is being done on rheumatoid arthritis?
    • Where can people get additional information on rheumatoid arthritis?
  • Lupus Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease....learn more »
    In This Article
    Lupus Article
    • Systemic lupus erythematosus facts
    • What is systemic lupus erythematosus? What are the types of lupus?
    • What causes systemic lupus erythematosus? Is lupus hereditary?
    • What is drug-induced lupus?
    • What are lupus symptoms and signs?
    • How is systemic lupus erythematosus diagnosed?
    • What is the treatment for systemic lupus?
    • How can a lupus patient help prevent disease activity (flares)?
    • How can systemic lupus erythematosus affect pregnancy or the newborn?
    • What is the prognosis of lupus? What does the future hold for people with systemic lupus?
    • Where can one get more information about systemic lupus erythematosus?
  • Crohn's Disease Crohn's disease is a chronic inflammatory disease, primarily involving the small and large intestine, but which can affect...learn more »
    In This Article
    Crohn's Disease Article
    • Crohn's disease facts
    • What is Crohn's disease?
    • What causes Crohn's disease?
    • How does Crohn's disease affect the intestines?
    • How is Crohn's disease different from ulcerative colitis?
    • What are the symptoms of Crohn's disease?
    • What are the complications of Crohn's disease?
    • How is Crohn's disease diagnosed?
    • How is Crohn's disease treated?
    • Crohn's Disease Medications
    • Anti-inflammatory medications
    • 5-ASA (mesalamine) oral medications
    • 5-ASA rectal medications (Rowasa, Canasa)
    • Corticosteroids
    • Budesonide (Entocort EC)
    • Antibiotics
    • Immuno-modulator medications
    • Azathioprine (Imuran) and 6-mercaptopurine (6-MP, Purinethol)
    • Infliximab (Remicade)
    • Adalimumab (Humira)
    • Certolizumab pegol (Cimzia)
    • Natalizumab (Tysabri)
    • Methotrexate
    • Surgery in Crohn's disease
    • Are there any recommendations for diet and supplementation for Crohn's disease?
    • Conclusions
  • Sarcoidosis Sarcoidosis, a disease resulting from chronic inflammation, causes small lumps (granulomas) to develop in a great range of body...learn more »
    In This Article
    Sarcoidosis Article
    • Sarcoidosis facts
    • What is sarcoidosis?
    • What are symptoms of sarcoidosis?
    • Who gets sarcoidosis?
    • What we know about sarcoidosis
    • Some things we don't know about sarcoidosis
    • How is sarcoidosis diagnosed?
    • What are some signs and symptoms that suggest possible sarcoidosis?
    • What do laboratory tests show?
    • How is sarcoidosis treated?
    • Living with sarcoidosis
    • Where can a person find more information on sarcoidosis?
  • Ulcerative Colitis Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding....learn more »
    In This Article
    Ulcerative Colitis Article
    • Ulcerative colitis facts
    • What is ulcerative colitis?
    • What causes ulcerative colitis?
    • What are the symptoms of ulcerative colitis?
    • How is the diagnosis of ulcerative colitis made?
    • What are the complications of ulcerative colitis?
    • What are the treatments for ulcerative colitis?
    • What are ulcerative colitis medications?
    • 5-ASA Compounds
    • Systemic corticosteroids (including side effects)
    • Golimumab (Simponi)
    • What are immunomodulator medications?
    • Summary of medication treatment
    • Surgery for ulcerative colitis
    • Treatment by disease severity and location (based on ACG Practice Guidelines)
    • Are there any special dietary requirements for persons with ulcerative colitis?
    • What research is being done regarding ulcerative colitis?
  • Ankylosing Spondylitis Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing...learn more »
    In This Article
    Ankylosing Spondylitis Article
    • Ankylosing spondylitis facts
    • What is ankylosing spondylitis?
    • What causes ankylosing spondylitis?
    • What are ankylosing spondylitis symptoms and signs?
    • How is ankylosing spondylitis diagnosed?
    • What are ankylosing spondylitis treatment options?
    • Can ankylosing spondylitis be prevented?
    • What is the prognosis (outlook) for patients with ankylosing spondylitis?
    • What is in the future for patients with ankylosing spondylitis?
    • Where can people find more information about ankylosing spondylitis and learn about support groups?
  • Vasculitis Vasculitis is a general term for a group of uncommon diseases which feature inflammation of the blood vessels. Each form of...learn more »
    In This Article
    Vasculitis Article
    • Vasculitis facts
    • What is vasculitis?
    • What causes vasculitis, and what are examples of diseases with vasculitis?
    • What are the symptoms of vasculitis?
    • How is vasculitis diagnosed?
    • How is vasculitis treated?
  • Male Breast Cancer Male breast cancer accounts for 1% of all breast cancers, and most cases are found in men between the ages of 60 and 70. A man's...learn more »
    In This Article
    Male Breast Cancer Article
    • Male breast cancer facts
    • What is male breast cancer?
    • How common is male breast cancer?
    • What are causes and risk factors of male breast cancer?
    • What are the different types of male breast cancer?
    • What are male breast cancer symptoms and signs?
    • How is male breast cancer diagnosed?
    • What is staging of male breast cancer?
    • What is the treatment for male breast cancer?
    • What is the outcome (prognosis) of male breast cancer?
  • Psoriatic Arthritis Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms include painful, stiff, and swollen joints,...learn more »
    In This Article
    Psoriatic Arthritis Article
    • Psoriatic arthritis facts
    • What is psoriatic arthritis?
    • What causes psoriatic arthritis?
    • What are risk factors for developing psoriatic arthritis?
    • What are psoriatic arthritis symptoms and signs?
    • How does the doctor diagnose psoriatic arthritis?
    • What is the treatment for psoriatic arthritis?
    • Disease-modifying medications
    • What are complications of psoriatic arthritis?
    • What is the outlook (prognosis) for patients with psoriatic arthritis?
    • Can psoriatic arthritis be prevented?
    • What does the future hold for patients with psoriatic arthritis?
  • Pulmonary Fibrosis Pulmonary fibrosis is scarring throughout the lungs. Pulmonary fibrosis can be caused by many conditions including chronic...learn more »
    In This Article
    Pulmonary Fibrosis Article
    • What is pulmonary fibrosis?
    • What are causes and symptoms of pulmonary fibrosis?
    • How is pulmonary fibrosis diagnosed?
    • How is pulmonary fibrosis treated?
    • What are the complications of pulmonary fibrosis?
    • Can pulmonary fibrosis be prevented?
    • What is the prognosis for pulmonary fibrosis?
    • Where can I get information to improve the quality of life for those with pulmonary fibrosis?
  • Scalp Psoriasis Scalp psoriasis causes red, raised, scaly patches that may extend from the scalp to the forehead and the back of the neck and...learn more »
    In This Article
    Scalp Psoriasis Article
    • What is scalp psoriasis?
    • What is the cause of scalp psoriasis?
    • What are scalp psoriasis symptoms and signs?
    • How is scalp psoriasis diagnosed?
    • What are topical treatments and home remedies for scalp psoriasis?
    • What are office treatments for scalp psoriasis?
    • What are systemic treatments for psoriasis?
    • What is the prognosis of psoriasis? Is there a cure for psoriasis?
    • Are there support groups for individuals with psoriasis?
  • Optic Neuritis Optic neuritis is inflammation of the optic nerve, the structure that connects the eye to the brain. The precise cause of optic...learn more »
    In This Article
    Optic Neuritis Article
    • Optic neuritis facts
    • What is optic neuritis?
    • What causes optic neuritis?
    • What are symptoms of optic neuritis?
    • What are signs of optic neuritis?
    • How is optic neuritis diagnosed?
    • What is the treatment for optic neuritis?
    • What is the prognosis for optic neuritis?
    • Where can I find more information on optic neuritis?
  • Scleroderma Scleroderma is an autoimmune disease of the connective tissue. It is characterized by the formation of scar tissue (fibrosis) in...learn more »
    In This Article
    Scleroderma Article
    • Scleroderma facts
    • What is scleroderma?
    • What causes scleroderma?
    • What are risk factors for developing scleroderma?
    • How is scleroderma classified?
    • What are scleroderma symptoms and signs?
    • How is scleroderma diagnosed?
    • What is the treatment for scleroderma?
    • What is the prognosis (outlook) for patients with scleroderma?
    • Can scleroderma be prevented?
  • Myasthenia Gravis Myasthenia gravis, a chronic autoimmune neuromuscular disease. Varying degrees of weakness of the voluntary muscles of the body...learn more »
    In This Article
    Myasthenia Gravis Article
    • Myasthenia gravis facts*
    • What is myasthenia gravis?
    • What causes myasthenia gravis?
    • What is the role of the thymus gland in myasthenia gravis?
    • What are the symptoms of myasthenia gravis?
    • Who gets myasthenia gravis?
    • How is myasthenia gravis diagnosed?
    • How is myasthenia gravis treated?
    • What are myasthenic crises?
    • What is the prognosis?
    • What research is being done?
    • Where can I get more information?
  • Polymyositis Polymyositis is a disease of the muscle featuring inflammation of the muscle fibers. It results in weakness of the muscles which...learn more »
    In This Article
    Polymyositis Article
    • Polymyositis facts
    • What is polymyositis?
    • What causes polymyositis?
    • What are symptoms of polymyositis?
    • How does the doctor diagnose polymyositis?
    • How is polymyositis treated?
    • What is the prognosis for polymyositis?
    • What are risk factors for worse outcomes with polymyositis?
    • Can polymyositis be prevented?
    • Where can people find more information on polymyositis and dermatomyositis?
  • Uveitis Uveitis is inflammation of the eye. Symptoms include blurred vision, eye pain, eye redness, photophobia, and floaters. Treatment...learn more »
    In This Article
    Uveitis Article
    • What is uveitis?
    • What causes uveitis?
    • What are symptoms of uveitis?
    • What are the signs of uveitis?
    • What are the different types of uveitis?
    • What other medical conditions are associated with uveitis?
    • How is uveitis diagnosed?
    • What is the treatment for uveitis?
    • What is the prognosis for uveitis?
    • What are the complications of uveitis?
    • Can uveitis be prevented?
  • Scleritis Scleritis is inflammation of the white part of the eye. It may be caused by a serious underlying condition, such as an autoimmune...learn more »
    In This Article
    Scleritis Article
    • Scleritis facts
    • What is scleritis?
    • What is the sclera?
    • What causes scleritis?
    • What are risk factors for scleritis?
    • What are symptoms of scleritis?
    • What are signs of scleritis?
    • How is scleritis diagnosed?
    • What is the treatment for scleritis?
    • What are the complications of scleritis?
    • What is the prognosis for scleritis?
    • Can scleritis be prevented?
    • What research is being done on scleritis?
  • Wegener's Granulomatosis Wegener's granulomatosis, a condition that usually affects young or middle-aged adults, is an inflammation of the arteries...learn more »
    In This Article
    Wegener's Granulomatosis Article
    • Wegener's granulomatosis facts
    • What is Wegener's granulomatosis?
    • What are symptoms of Wegener's granulomatosis?
    • How is Wegener's granulomatosis diagnosed?
    • How is Wegener's granulomatosis treated?
  • Bullous Pemphigoid Bullous pemphigoid is a skin disease that causes blistering eruptions on the skin's surface and sometimes affects the inner...learn more »
    In This Article
    Bullous Pemphigoid Article
    • What is bullous pemphigoid?
    • What are symptoms of bullous pemphigoid?
    • How is bullous pemphigoid diagnosed?
    • What is the treatment for bullous pemphigoid?
    • What is the prognosis of bullous pemphigoid?
  • Reactive Arthritis Reactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint...learn more »
    In This Article
    Reactive Arthritis Article
    • Reactive arthritis facts
    • What is reactive arthritis?
    • What causes reactive arthritis?
    • What are risk factors for developing reactive arthritis?
    • What are reactive arthritis symptoms and signs?
    • How is reactive arthritis diagnosed?
    • How is reactive arthritis treated?
    • What is the prognosis of reactive arthritis?
    • Can reactive arthritis be prevented?
    • What does the future hold for reactive arthritis?
  • Relapsing Polychondritis Relapsing polychondritis is an uncommon, chronic disorder of the cartilage that is characterized by recurrent episodes of...learn more »
    In This Article
    Relapsing Polychondritis Article
    • Relapsing polychondritis facts
    • What is relapsing polychondritis?
    • What causes relapsing polychondritis?
    • What are symptoms and signs of relapsing polychondritis?
    • How is relapsing polychondritis diagnosed?
    • Can relapsing polychondritis be associated with other diseases?
    • What medications are used to treat relapsing polychondritis?
    • What is the long-term outlook (prognosis) for patients with relapsing polychondritis?
  • Still's Disease Still's disease (Systemic-Onset Juvenile Rheumatoid Arthritis) is a disorder characterized by inflammation with high fever...learn more »
    In This Article
    Still's Disease Article
    • Still's disease facts
    • What is Still's disease?
    • What causes Still's disease?
    • What are risk factors for Still's disease?
    • How does Still's disease relate to juvenile idiopathic arthritis?
    • What are symptoms and signs of Still's disease?
    • How is Still's disease diagnosed?
    • What is the frequency of Still's disease and its features?
    • What is the treatment for Still's disease?
    • Is it possible to prevent Still's disease?
    • What Still's disease research is being done?
    • What is the outlook (prognosis) with Still's disease?
  • Juvenile Idiopathic Arthritis (Juvenile Rheumatoid Arthritis) Juvenile idiopathic arthritis (juvenile rheumatoid arthritis or JRA) annually affects one child in every thousand. There are six...learn more »
    In This Article
    Juvenile Idiopathic Arthritis (Juvenile Rheumatoid Arthritis) Article
    • Juvenile idiopathic arthritis (JIA) facts
    • What is juvenile idiopathic arthritis?
    • What are causes and risk factors of juvenile idiopathic arthritis?
    • What are juvenile idiopathic arthritis symptoms and signs, and how are the different types of juvenile idiopathic arthritis diagnosed?
    • What is the treatment for juvenile idiopathic arthritis?
    • What are complications of juvenile idiopathic arthritis?
    • What is the prognosis of juvenile idiopathic arthritis?
  • Cleft Palate and Cleft Lip Cleft palate and cleft lip are facial and oral defects that occur early in pregnancy. A cleft lip is a split of the two sides of...learn more »
    In This Article
    Cleft Palate and Cleft Lip Article
    • Cleft lip and cleft palate facts
    • What is a cleft lip? What is a cleft palate?
    • How often do cleft lip and cleft palate occur?
    • What are the causes and risk factors for developing a cleft lip and cleft palate?
    • How do physicians diagnose a cleft lip and cleft palate?
    • What are complications of a cleft lip and cleft palate?
    • What is the treatment for a cleft lip and cleft palate?
    • What is the prognosis for a cleft lip and cleft palate?
    • Is it possible to prevent a cleft lip or cleft palate?
  • Eosinophilic Fasciitis Eosinophilic fasciitis is a skin disease that causes thickening and inflammation of the skin and fascia. Symptoms include...learn more »
    In This Article
    Eosinophilic Fasciitis Article
    • What are eosinophils?
    • What is fascia?
    • What is eosinophilic fasciitis?
    • What causes eosinophilic fasciitis?
    • What are symptoms and signs of eosinophilic fasciitis?
    • How is eosinophilic fasciitis diagnosed?
    • What is the treatment for eosinophilic fasciitis?
    • What is the prognosis of eosinophilic fasciitis?
    • Can eosinophilic fasciitis be prevented?
  • In This Article
    Primary Biliary Cirrhosis (PBC) Article
    • Primary biliary cirrhosis (PBC) definition
    • What are the causes of primary biliary cirrhosis?
    • What are the risk factors for primary biliary cirrhosis?
    • What are the signs and symptoms for primary biliary cirrhosis?
    • How is the diagnosis of primary biliary cirrhosis made?
    • What is the treatment for primary biliary cirrhosis?
    • What are the complications of primary biliary cirrhosis?
    • Can primary biliary cirrhosis be prevented?
    • What is the prognosis for someone with primary biliary cirrhosis?
  • SAPHO Syndrome SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO syndrome is an eponym for the combination of...learn more »
    In This Article
    SAPHO Syndrome Article
    • SAPHO syndrome facts
    • What is SAPHO syndrome?
    • What causes SAPHO syndrome, and what are risk factors for developing it?
    • Is SAPHO syndrome related to other joint conditions?
    • What are symptoms and signs of SAPHO syndrome?
    • How is SAPHO syndrome diagnosed?
    • What is the treatment for SAPHO syndrome?
    • What is the outlook (prognosis) for patients with SAPHO syndrome?
    • Can SAPHO syndrome be prevented?
  • Primary Sclerosing Cholangitis (PSC) Primary sclerosing cholangitis or PSC is a disease of the liver. The cause of PSC is not known. Symptoms may include itching,...learn more »
    In This Article
    Primary Sclerosing Cholangitis (PSC) Article
    • Primary sclerosing cholangitis (PSC) definition
    • What causes primary sclerosing cholangitis?
    • What are the risk factors for primary sclerosing cholangitis?
    • What are the signs and symptoms of primary sclerosing cholangitis?
    • How is the diagnosis of primary sclerosing cholangitis made?
    • What is the treatment for primary sclerosing cholangitis?
    • Medications
    • Liver transplant
    • What complications are associated with primary sclerosing cholangitis?
    • Can primary sclerosing cholangitis be prevented?
    • What is the prognosis and life expectancy for a person with primary sclerosing cholangitis?
  • Felty's Syndrome Felty's syndrome is a complication of long-term rheumatoid arthritis. Felty's syndrome is defined by the presence of three...learn more »
    In This Article
    Felty's Syndrome Article
    • Felty's syndrome facts
    • What is Felty's syndrome?
    • What are the symptoms of Felty's syndrome?
    • What causes Felty's syndrome?
    • How is Felty's syndrome diagnosed?
    • How is Felty's syndrome treated?
  • Takayasu Disease Takayasu disease (also referred to as Takayasu arteritis) is a chronic inflammation of the aorta and it's branch arteries....learn more »
    In This Article
    Takayasu Disease Article
    • Takayasu disease facts
    • What is Takayasu disease?
    • What causes Takayasu disease?
    • What are symptoms of Takayasu disease?
    • How is Takayasu disease diagnosed?
    • How is Takayasu disease treated?
    • What is the long-term prognosis for patients with Takayasu disease?
    • Can Takayasu disease be prevented?
  • Eczema Eczema, also known as dermatitis, is a general term for many types of skin inflammation. The most common form of eczema is atopic...learn more »
    In This Article
    Eczema Article
    • Eczema facts
    • What is eczema?
    • What are the causes of eczema?
    • What are risk factors for eczema?
    • What are eczema symptoms and signs in babies, children, and adults?
    • What are the different types of eczema?
    • How is eczema diagnosed?
    • What is the home remedies and treatment for eczema?
    • Can eczema be prevented?
    • What are the possible complications of eczema?
    • What is the prognosis (outlook) for eczema?
  • In This Article
    Primary Biliary Cirrhosis Treatment (PBC) Article
    • PBC facts
    • What treatments are used in patients with PBC?
    • What medications are used to treat PBC itself?
    • Ursodeoxycholic acid (UDCA)
    • Colchicine
    • Immunosuppressive medications
    • What treatments are used for the symptoms of PBC?
    • Itching
    • Osteoporosis
    • Elevated serum cholesterol and xanthomas
    • Malabsorption of fat and fat-soluble vitamins (A, D, E and K)
    • What treatments are used for the complications of the cirrhosis in PBC?
    • Edema and ascites
    • Bleeding from varices
    • Hepatic encephalopathy
    • Hypersplenism
    • What treatments are used for the diseases associated with PBC?
    • Sicca Syndrome
    • Raynaud's Phenomenon
    • Scleroderma
    • Gallstones
    • What is the role of liver transplantation in PBC?
    • What is the future for PBC?