methotrexate, Rheumatrex, Trexall (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

NURSING MOTHERS: Methotrexate is excreted in breast milk and should not be used by nursing mothers.

SIDE EFFECTS: Methotrexate can cause severe toxicity which usually is related to the dose taken. The most frequent reactions include mouth sores, stomach upset, and low white blood counts. Methotrexate can cause severe toxicity of the liver, kidneys and bone marrow, which require regular monitoring with blood tests. It can cause headache and drowsiness which may resolve if the dose is lowered. Methotrexate can cause itching, skin rash, dizziness, and hair loss. A dry, non-productive cough can be a result of rare lung toxicity.

Reference: FDA Prescribing Information


Last Editorial Review: 3/28/2013



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