USES: Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. This medication works by interfering with cell growth and by suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.

OTHER USES: This medication has also been used to treat other disorders such as lupus, psoriatic arthritis, and ectopic pregnancy.

HOW TO USE: This medication is given by injection by a healthcare professional. The dose and frequency of use are based on your medical condition and response to therapy. Follow all directions for proper mixing. Before using, check this medication visually for particles or discoloration. If either is present, do not use the liquid. If you have questions regarding the use of this medication, consult the pharmacist. Methotrexate formulations with preservatives must not be used for high-dose treatment or injected into the spine (intrathecal).

SIDE EFFECTS: See also Warning section. Nausea, vomiting, stomach pain, drowsiness or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these serious side effects occur: mouth sores, diarrhea, fever, fatigue, persistent sore throat, unusual bleeding or bruising, black stools, skin rash, enlarged glands/lymph nodes, dark urine, bone pain, unusual pain and discoloration of the skin. Tell your doctor immediately if any of these unlikely but serious side effects occur: yellowing eyes/skin, change in the amount of urine, chest pain, dry cough, trouble breathing, calf pain/swelling, vision changes, irregular heartbeat, muscle weakness, severe headache, neck stiffness, mental/mood changes, seizures. Temporary hair loss may occur. Normal hair growth should return after treatment has ended. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.