methocarbamol (Robaxin, Robaxin-750)

  • Pharmacy Author:
    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies of methocarbamol to determine safe and effective use in pregnant women. Methocarbamol should be avoided in pregnant mothers to avoid any risk to the unborn.

It is not known whether methocarbamol enters breast milk. It should be avoided in nursing mothers to prevent any adverse effects to the newborn.

STORAGE: Store methocarbamol tablets between 20 C – 25 C (68 F – 77 F). Store methocarbamol injection preparations between temperatures of 15 C - 30 C (59 F – 86 F).

DOSING:

Musculoskeletal pain in adults:

  • Initially, take three 500 mg tablets by mouth 4 times a day for first 48 to 72 hours, then take 2 tablets by mouth 4 times a day for the maintenance of spasms.
  • If using 750 mg tablets take 2 tablets by mouth 4 times a day for the first 48 to 72 hours, then take 1 tablet by mouth every 4 hours or take 2 tablets by mouth 3 times a day for the maintenance of spasms.
  • The dose for injections is 1 gram intravenously or intramuscularly every 8 hours with a maximum dose of 3 grams per day for 3 days.
    • If needed, the same course may be repeated after a 48 hour drug free interval.

Tetanus spasms:

  • Adults: Inject 1 to 2 grams intravenously every 6 hours as needed with a maximum dose of 24 grams per day.
  • Children: Inject 15 mg/kg intravenously every 6 hours as needed.
    • The total dose should not exceed 1.8 g/m2 for 3 consecutive days.

DRUG CLASS AND MECHANISM: Methocarbamol is a skeletal muscle relaxant with sedative effects. The exact mechanism of how methocarbamol works is not known. Methocarbamol is presumed to work by depressing the central nervous system, leading to relaxation of muscles. The FDA approved methocarbamol in July 1957.

Medically reviewed by Eni Williams, PharmD, PhD

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 7/1/2016

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