methadone liquid-oral (cont.)

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription drugs you use, especially of: MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), psychiatric drugs (e.g., desipramine), tranquilizers, sleep medications (e.g., zolpidem), zidovudine, didanosine, stavudine, nevirapine, efavirenz, ritonavir, ritonavir/lopinavir, other narcotic pain relievers, drugs which affect certain liver enzymes (CYP 3A4 substrates, inhibitors, and inducers such as St John's wort, cimetidine, azole antifungals--itraconazole, macrolide antibiotics--erythromycin, rifamycins--rifampin, certain anti-seizure medications--phenobarbital, phenytoin, carbamazepine), certain antihistamines (e.g., diphenhydramine) or other drugs which can also cause drowsiness. Other drugs besides methadone which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, procainamide, quinidine, sotalol, sparfloxacin, "water pills" (diuretics such as furosemide), and laxatives among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Other symptoms may include unusual dizziness or fainting. Seek immediate medical attention should these occur. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include cold and clammy skin, low body temperature, slowed breathing, slowed heartbeat, drowsiness, dizziness, lightheadedness, deep sleep, and loss of consciousness.

NOTES: Do not share this medication with others. It is against the law. Laboratory and/or medical tests (e.g., EKG-QTc interval) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

STORAGE: Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.

Last Editorial Review: 3/2/2005

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