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- What is methadone liquid-oral, and how does it work (mechanism of action)?
- What brand names are available for methadone liquid-oral?
- Is methadone liquid-oral available as a generic drug?
- Do I need a prescription for methadone liquid-oral?
- What are the uses for methadone liquid-oral?
- What are the side effects of methadone liquid-oral?
- What is the dosage for methadone liquid-oral?
- Which drugs or supplements interact with methadone liquid-oral?
- Is methadone liquid-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about methadone liquid-oral?
What is the dosage for methadone liquid-oral?
- The initial dose of oral methadone in patients who require continuous pain control throughout the day can range from 2.5 to 10 mg given every 8 to 12 hours.
- Those who are seriously ill may need to be started at an oral dose of 10 to 40 mg given every 6 to 12 hours.
- The initial total daily dose for detoxification usually is higher, and this can range from 20 to 120 mg daily.
- The usual dose for methadone solution for injection when treating moderate to severe pain in patients who require continuous pain control is 2.5 to 10 mg given as intravenous (I.V.), subcutaneous (SubQ) or intramuscular (I.M.) injection every 8-12 hours.
- The conversion ratio from oral methadone to methadone given as an injection (I.V., SubQ) or I.M.) is 2:1. The total daily amount of methadone that a person is prescribed is not fixed, and it will depend on many factors including the severity of the pain, prior use of methadone, medications that are being taken concomitantly, the response to treatment and other factors that may be specific to a person.
- Therefore, each person has to be monitored carefully while receiving methadone. When stopping therapy, the dose of methadone should be gradually reduced in order to avoid withdrawal symptoms.
Which drugs or supplements interact with methadone liquid-oral?
- Methadone when taken with drugs that slow brain function, such as alcohol and barbiturates (phenobarbital), can increase the effects of these drugs.
- Because methadone causes constipation, taking antidiarrheal medications such as diphenoxylate (Lomotil) and loperamide (Imodium) along with methadone can result in severe constipation.
- Drugs that block narcotic (opioid) receptors including pentazocine (Talwin), nalbuphine (Nubain), naloxone (Narcan), butorphanol (Stadol) and buprenorphine (Subutex) can lead to withdrawal symptoms.
- Rifampin (Rifadin), barbiturates, carbamazepine (Tegretol), phenytoin (Dilantin), primidone and St. John's wort preparations can increase the liver's ability to metabolize (eliminate) methadone and reduce its blood concentration which could result in withdrawal side effects, while drugs such as erythromycin (E-Mycin, Eryc, Ery-Tab), clarithromycin (Biaxin, Biaxin XL), ketoconazole (Nizoral), and itraconazole (Sporanox) can decrease the liver's ability to metabolize methadone thereby increasing the side effects of this drug.
- Anti-retroviral agents including abacavir (Ziagen), amprenavir (Agenerase), efavirenz (Sustiva), nelfinavir (Viracept), Nevirapine (Viramune, Viramune XR), Ritonavir (Norvir), and lopinavir/ ritonavir (Kaletra) have been shown to decreased the blood levels of methadone making it necessary to adjust the dose of methadone to prevent narcotic withdrawal effects.
- Some drugs that slow the heart rate for example, dofetilide (Tikosyn), procainamide (Pronestyl, Procan-SR), quinidine, and sotalol (Betapace), as well as laxatives and diuretics that cause low magnesium or low potassium in the body, for example, furosemide (Lasix), can cause rare serious and fatal irregular heartbeats.
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