methadone (Dolophine; Methadone HCl Intensol; Methadose; Methadose Sugar-Free)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: Methadone
BRAND NAME: Dolophine; Methadone HCl Intensol; Methadose; Methadose Sugar-Free
DRUG CLASS AND MECHANISM: Methadone is a strong, synthetic (man-made) narcotic that acts on the central nervous system (brain) in a manner similar to other narcotics. It is used in the management of narcotic addiction and for pain control. Methadone was first approved by the Food and Drug Administration on August 13 1947.
GENERIC AVAILABLE: Yes
STORAGE: Oral methadone and injection should be stored at room temperature between 15 C and 30 C (59 F and 86 F). Methadone injection also should be protected from light.
PRESCRIBED FOR: Methadone is used for the treatment of moderate to severe pain when non-narcotic pain medications have failed. The extended release methadone tablets should be reserved for severe and continuous pain that requires long-term pain treatment after a failed trial of non-narcotic medications and should be avoided in individuals requiring as-needed pain control.
DOSING: The initial dose of oral methadone in patients who require continuous pain control throughout the day can range from 2.5 to 10 mg given every 8 to 12 hours. Those who are seriously ill may need to be started at an oral dose of 10-40 mg given every 6-12 hours. The initial total daily dose for detoxification usually is higher, and this can range from 20 to 120 mg daily. The usual dose for methadone solution for injection when treating moderate to severe pain in patients who require continuous pain control is 2.5 to 10mg given as intravenous (I.V.), subcutaneous (SubQ) or intramuscular (I.M.) injection every 8-12 hours.
Medically Reviewed by a Doctor on 4/16/2014
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