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- What is mesalamine (Lialda), and how does it work (mechanism of action)?
- What brand names are available for mesalamine (Lialda)?
- Is mesalamine (Lialda) available as a generic drug?
- Do I need a prescription for mesalamine (Lialda)?
- What are the uses for mesalamine (Lialda)?
- What are the side effects of mesalamine (Lialda)?
- What is the dosage for mesalamine (Lialda)?
- Which drugs or supplements interact with mesalamine (Lialda)?
- Is mesalamine (Lialda) safe to take if I'm pregnant or breastfeeding?
- What else should I know about mesalamine (Lialda)?
What is mesalamine (Lialda), and how does it work (mechanism of action)?
- Mesalamine is an oral drug used for treating ulcerative colitis.
- Lialda is mesalamine in a form that is slowly released in the intestine so that it can be given just once-a-day.
- Other oral drugs containing mesalamine that are similar to Lialdainclude Asacol, Pentasa, and Apriso.
- Asacol and Pentasa, however, are given as multiple daily doses.
- The exact mechanism of mesalamine is not known but is believed to be by reducing inflammation in the colon.
- Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals (i.e., prostaglandins) that produce inflammation in the colon.
- Prostaglandins are produced by cyclooxygenase and lipoxygenase enzymes.
- These enzymes are over-active in individuals with ulcerative colitis.
- Mesalamine may work by blocking the activity of cyclooxygenase and lipoxygenase, therefore, reducing the production of prostaglandins.
- Reduced prostaglandin production reduces inflammation in the colon and other symptoms associated with ulcerative colitis.
- The FDA approved Lialda in January 2007.
What brand names are available for mesalamine (Lialda)?
Is mesalamine (Lialda) available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for mesalamine (Lialda)?
What are the uses for mesalamine (Lialda)?
Lialda is used for inducing remission in patients with active, mild to moderate ulcerative colitis. In clinical studies which compared mesalamine against placebo for 8 weeks, more patients in the mesalamine group achieved remission.
What are the side effects of mesalamine (Lialda)?
The most common side effects are:
Other less common side effects include:
- increased heart rate,
- back pain,
- ear pain,
- blood disorders, and
- kidney dysfunction.
Possible serious side effects include an acute intolerance syndrome that resembles a flare of inflammatory bowel disease. Symptoms include:
Quick GuideUlcerative Colitis Symptoms, Causes, and Treatment
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