mesalamine, Lialda

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GENERIC NAME: mesalamine

BRAND NAME: Lialda

DRUG CLASS AND MECHANISM: Mesalamine is an oral drug used for treating ulcerative colitis . Lialda is mesalamine in a form that is slowly released in the intestine so that it can be given just once-a-day. Other oral drugs containing mesalamine that are similar to Lialdainclude Asacol, Pentasa, and Apriso. Asacol and Pentasa, however,are given as multiple daily doses. Rowasa .The exact mechanism of mesalamine is not known but is believed to be by reducing inflammation in the colon. Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals (i.e., prostaglandins) that produce inflammation in the colon. Prostaglandins are produced by cyclooxygenase and lipoxygenase enzymes. These enzymes are over-active in individuals with ulcerative colitis. Mesalamine may work by blocking the activity of cyclooxygenase and lipoxygenase, therefore, reducing the production of prostaglandins. Reduced prostaglandin production reduces inflammation in the colon and other symptoms associated with ulcerative colitis. The FDA approved Lialda in January 2007.

GENERIC AVAILABLE: No

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 1.2 g




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