meropenem (Merrem)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Serious hypersensitivity (allergic) reactions may occur.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Intravenous powder for solution: 500 mg/vial and 1 gram/vial.

STORAGE: Meropenem should be stored at room temperature, 20 C to 25 C (68 F to 77 F).

DOSING:

  • For the treatment of complicated skin infections in adults, 500 mg to 2 grams should be administered intravenously every 8 hours.
  • For abdominal infections, 1 to 2 grams should be administered intravenously every 8 hours.

DRUG INTERACTIONS: Meropenem should not be combined with valproic acid (Depakene) or divalproex (Depakote) because meropenem may reduce absorption of valproic acid and divalproex from the intestine and increase elimination of the drugs through the kidneys thereby reducing the levels of these drugs in the body and reducing their effectiveness.

Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache.

PREGNANCY: Safe and effective use of meropenem is not established in pregnant females. Therefore, it should be used only if clearly needed.

NURSING MOTHERS: It is not known whether meropenem enters breast milk.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 12/24/2014

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