memantine, Namenda, Namenda XR

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Quick Guide to Dementia

PREPARATIONS:

  • Tablets: 5 and 10 mg.
  • Capsule (extended release): 7, 14, 21 and 28 mg.
  • Solution: 2 mg/ml.

DRUG INTERACTIONS:

  • Medicines that make the urine more alkaline (for example, carbonic anhydrase inhibitors such as acetazolamide (Diamox) and sodium bicarbonate would be expected to reduce the elimination of memantine by the kidneys and might increase the blood levels and the risk of side effects of memantine.
  • Combining memantine with other NMDA receptor antagonists (for example, amantadine [Symmetrel], ketamine, and dextromethorphan) has not been evaluated and should be done cautiously.

PREGNANCY AND BREASTFEEDING SAFETY:

  • Memantine given in high doses to pregnant rats and rabbits did not affect the offspring. However, studies have not been conducted in pregnant women. Memantine should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.
  • It is not known if memantine is excreted into breast milk.

STORAGE: Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING:

  • The usual starting dose of memantine tablets is 5 mg once daily.
  • The dose usually is increased to 5 mg twice daily, then 5 mg and 10 mg as separate doses daily, and finally 10 mg twice daily.
  • Memantine can be taken with or without food.
  • The initial recommended dose of memantine capsules is 7 mg daily.
  • The dose may be increased weekly by 7 mg daily and the maximum dose is 28 mg daily.
  • Capsules may be swallowed whole or opened and sprinkled on spoonsful of applesauce.
  • Capsules should not be crushed or chewed.
Medically Reviewed by a Doctor on 6/20/2016

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