Melatonin

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Insomnia Pictures: 10 Tips to Avoid Insomnia

DRUG INTERACTIONS: Melatonin should be used with caution with birth control medications and fluvoxamine (Luvox) because they increase melatonin levels in the body and cause increased sedation.

Melatonin should be used with caution with medications like:

These drugs cause increased sedation.

Melatonin should be used with caution with medications like:

These drugs increase the risk of bleeding and bruising.

PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies done on melatonin to determine safe and effective use in pregnant women.

It is not known whether melatonin enters breast milk. It is best for nursing mothers to avoid using melatonin.

STORAGE: Melatonin is usually stored at room temperature.

DOSING:

  • Sleeplessness, sleep-wake cycle changes: Take 0.3 to 5 mg by mouth daily at bedtime.
  • Migraine headaches: Take 3 to 10 mg by mouth daily at bedtime.

DRUG CLASS AND MECHANISM: Melatonin is a natural hormone produced by the pineal gland in the body. Commercially available melatonin that is sold as medicine is produced in the laboratory. Melatonin regulates sleep-wake cycle. Check with your healthcare professional before using herbs or other supplements.

Medically reviewed by Eni Williams, PharmD, PhD

REFERENCE:

Medscape: Melatonin (Herbs/Suppl) N-acetyl-5-methoxytryptamine, pineal hormone


Medline Plus, National Library of Medicine
http://nccam.nih.gov/health/melatonin

Medically Reviewed by a Doctor on 7/1/2016
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