melatonin - oral (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Melatonin should be used with caution with birth control medications and fluvoxamine (Luvox) because they increase melatonin levels in the body and cause increased sedation.

Melatonin should be used with caution with medications like zolpidem (Ambien), alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), and zalepon (Sonata) because they cause increased sedation.

MMelatonin should be used with caution with medications like aspirin, heparin, warfarin (Coumadin), clopidogrel (Plavix), diclofenax (Voltaren), and meloxicam (Mobic) because they increase the risk of bleeding and bruising.

PREGNANCY: There are no adequate studies done on melatonin to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether melatonin enters breast milk. It is best for nursing mothers to avoid using melatonin.

SIDE EFFECTS: Side effects of melatonin are dizziness, drowsiness, fatigue, stomach discomfort, decreased alertness, headache, and irritability.


Medscape: Melatonin (Herbs/Suppl) N-acetyl-5-methoxytryptamine, pineal hormone

Medline Plus, National Library of Medicine

Medically Reviewed by a Doctor on 10/10/2014

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