megestrol, Megace, Megace ES (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Indinavir (Crixivan) reduces blood concentrations of megestrol. An increase in the dose of megestrol should be considered.

PREGNANCY: Megestrol may cause birth defects and should not be administered to pregnant women. Women should use contraception while taking megestrol.

NURSING MOTHERS: Megestrol should not be used while breastfeeding due to potential adverse effects in the infant.

SIDE EFFECTS: The most common side effects are diarrhea, weight gain, nausea, rash, impotency, insomnia, mood swings, sweating, breakthrough menstrual bleeding, high blood pressure, and the production of excess gas (flatulence). Blood clots in legs and lungs may occur. Megestrol may worsen existing diabetes or lead to new onset diabetes.

Reference: FDA Prescribing Information

Last Editorial Review: 3/21/2012

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