megestrol, Megace, Megace ES

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Blood clots in legs and lungs may occur.

Megestrol may worsen existing diabetes or lead to new onset diabetes.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 20 and 40 mg. Oral suspension: 40 mg/mL or 125 mg/mL.

STORAGE: Megestrol should be stored in a dry place at room temperature, 15 C-25 C (59 F-77 F).

DOSING: The recommended dose for stimulating appetite is 800 mg per day of the regular megestrol suspension (40 mg/ml) or 625 mg per day of the ES formulation (125 mg/ml). Breast cancer is treated with 40 mg four times daily.

DRUG INTERACTIONS: Indinavir (Crixivan) reduces blood concentrations of megestrol. An increase in the dose of megestrol should be considered.

PREGNANCY: Megestrol may cause birth defects and should not be administered to pregnant women. Women should use contraception while taking megestrol.

NURSING MOTHERS: Megestrol should not be used while breastfeeding due to potential adverse effects in the infant.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 3/19/2015

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