medroxyprogesterone acetate (anticancer agent) - injection, Depo-Provera (cont.)

PRECAUTIONS: Before using medroxyprogesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of stroke or other blood clots (such as in the legs, eyes, lungs), breast cancer, family history of breast cancer, abnormal breast exam, cancer of the cervix, abnormal/unexplained vaginal bleeding, liver disease, current/suspected pregnancy, depression, frequent use of alcohol/tobacco, asthma, diabetes, heart disease (such as chest pain, heart failure, high blood pressure), kidney disease, migraine, seizures, personal/family history of bone disease (such as osteoporosis).Before having surgery, tell your doctor or dentist about all of the products you use (including prescription drugs, nonprescription drug, and herbal products).This medication must not be used during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, tell your doctor immediately.This drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some of the products that may interact with this drug include: acitretin, aminoglutethimide, corticosteroids (such as hydrocortisone, prednisone), isotretinoin, phenytoin, sodium tetradecyl sulfate, warfarin.Certain drugs can decrease the amount of medroxyprogesterone in your system. These drugs include aprepitant, bexarotene, bosentan, certain cephalosporin antibiotics (ceftazidime, cefuroxime), griseofulvin, HIV protease inhibitors (such as atazanavir, nelfinavir, ritonavir), other HIV medications (efavirenz, nevirapine), certain drugs for narcolepsy (armodafinil, modafinil), rifamycins (such as rifampin), many seizure medications (such as barbiturates, carbamazepine, rufinamide, topiramate), St. John's wort. Consult your doctor or pharmacist for details, and tell your doctor or pharmacist if you are taking any of the drugs listed above.This medication may interfere with certain laboratory tests (including certain hormone levels, thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you are using this medication.

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