medroxyprogesterone, Provera, Depo-Provera, Depo-Sub Q Provera 104 (cont.)

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PREGNANCY: Medroxyprogesterone inhibits fertility at high doses. It should not be given during pregnancy.

NURSING MOTHERS: Medroxyprogesterone is secreted in breast milk. The effect on the infant has not been determined.

SIDE EFFECTS: Breast tenderness and leakage of liquid from the nipple occur rarely with medroxyprogesterone. Various skin reactions, including hives, acne, hair growth and hair loss, also have been reported occasionally. Break-through bleeding (menstrual-like bleeding in the middle of the menstrual cycle), vaginal spotting of blood, changes in menstrual flow, increased or decreased weight, nausea, fever, insomnia, and jaundice have all been reported.

Blood clots are an occasional serious side effect of progestin therapy, and cigarette smokers are at a higher risk for clots. Therefore, females requiring progestin therapy are strongly encouraged to quit smoking.

People with diabetes may experience difficulty controlling blood glucose when taking medroxyprogesterone for unclear reasons. Therefore, increased monitoring of blood sugar and adjustment of medications for diabetes is recommended.

Medically Reviewed by a Doctor on 12/9/2014

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