medroxyprogesterone, Provera, Depo-Provera, Depo-Sub Q Provera 104 (cont.)

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STORAGE: Medroxyprogesterone should be stored at room temperature, between 20 C and 25 C (68 F and 77 F).

PRESCRIBED FOR: Medroxyprogesterone tablets are used for treating secondary amenorrhea (cessation of menstruation); abnormal bleeding from the uterus due to hormonal imbalance and not due to fibroids, or cancer; and to prevent endometrial hyperplasia (overgrowth of the endometrial lining) in postmenopausal women who have not undergone a hysterectomy and are receiving conjugated estrogens.

Medroxyprogesterone injection is used for contraception and for treating endometrial or renal cancer.

DOSING: The usual dose of medroxyprogesterone tablets is 5 or 10 mg daily.

  • Secondary amenorrhea is treated for 5 to 10 days.
  • Uterine bleeding is treated for 5 to 10 days beginning on day 16 or 21 of the menstrual cycle.
  • Endometrial hyperplasia is treated for 12 to 14 consecutive days beginning on day 1 or 16 of the menstrual cycle.
  • The dose for contraception is 150 mg every 3 months injected intramuscularly or 104 mg injected subcutaneously every 3 months.
  • The dose for endometrial or renal cancer is 400-1000 mg weekly initially followed by monthly maintenance doses.

DRUG INTERACTIONS: Aminoglutethimide (Cytadren) may increase the elimination of medroxyprogesterone by the liver leading to a decrease in the concentration of medroxyprogesterone in blood and possibly a reduction in the effectiveness of the medroxyprogesterone.

Medically Reviewed by a Doctor on 12/9/2014

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