medroxyprogesterone, Provera, Depo-Provera, Depo-Sub Q Provera 104

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GENERIC NAME: medroxyprogesterone acetate

BRAND NAME: Provera, Depo-Provera, Depo-Sub Q Provera 104

DRUG CLASS AND MECHANISM: Progestins and estrogens are the two major classes of female hormones. Medroxyprogesterone is a derivative of the naturally occurring female progestin, progesterone. Progestins are responsible for changes in the mucus and inner lining of the uterus (endometrium) during the second half (secretory phase) of the menstrual cycle. Progestins prepare the endometrium for implantation of the embryo. Once an embryo implants in the endometrium and pregnancy occurs, progestins help maintain the pregnancy. At high doses, progestins can prevent ovulation (release of the egg from the ovary) and thereby prevent pregnancy. Progestins were first isolated in 1933, and progesterone itself was synthesized in the 1940s.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Tablets: 2.5, 5, and 10 mg.
  • Intramuscular injection: 150 and 400 mg/ml.
  • Prefilled Syringe Suspension: 104 mg/0.65 ml

STORAGE: Medroxyprogesterone should be stored at room temperature, between 20 C and 25 C (68 F and 77 F).

PRESCRIBED FOR: Medroxyprogesterone tablets are used for treating secondary amenorrhea (cessation of menstruation); abnormal bleeding from the uterus due to hormonal imbalance and not due to fibroids, or cancer; and to prevent endometrial hyperplasia (overgrowth of the endometrial lining) in postmenopausal women who have not undergone a hysterectomy and are receiving conjugated estrogens.

Medically Reviewed by a Doctor on 12/9/2014



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